| Literature DB >> 28469840 |
Abstract
BACKGROUND: Prioritization of medical technologies requires a multi-dimensional view. Often, conflicting equity and efficiency criteria should be reconciled. The most dramatic manifestation of such conflict is in the prioritization of new medical technologies asking for public finance performed yearly by the Israeli Basket Committee. The aim of this paper is to compare the revealed preferences of the 2006/7 Basket Committee's members with the declared preferences of health policy-makers in Israel.Entities:
Keywords: Basket Committee; DCE; Efficiency; Equity; Health; Policymakers; Prioritization
Mesh:
Year: 2017 PMID: 28469840 PMCID: PMC5410368 DOI: 10.1186/s13584-017-0145-4
Source DB: PubMed Journal: Isr J Health Policy Res ISSN: 2045-4015
Relative weights of the equity and efficiency criteria
| Equity criteria | Efficiency criteria | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Number of respondents | The technology is intended for patients suffering from a serious disease (life expectancy is less than 2 healthy years): Yes | The Technology is intended to treat a disease common among children: Yes | The technology is intended to treat a disease common among the elderly: Yes | Funding the technology is required so that the poor can use it: Yes | Cost per Quality Adjusted Life Year: Less than the GNP per capita | The Number of patients requiring the technology: more than 100,000 | Individual Benefit: addition of more than 5 healthy years | Efficiency Weight | Equity Weight | Total | |
| Physicians | 25 | 11 | 16 | 9 | 20 | 12 | 14 | 18 | 44 | 56 | 100 |
| Non-physicians | 15 | 8 | 15 | 9 | 19 | 13 | 18 | 18 | 49 | 51 | 100 |
| Ever served on Basket Committee | 11 | 9 | 15 | 9 | 16 | 16 | 16 | 20 | 51 | 49 | 100 |
| Never did | 29 | 10 | 16 | 9 | 21 | 11 | 16 | 17 | 44 | 56 | 100 |
| Respondents answering the demographic questionnaire | 40 | 10 | 16 | 9 | 20 | 12 | 16 | 18 | 46 | 54 | 100 |
| Respondents not answering the demographic questionnaire | 25 | 13 | 11 | 12 | 17 | 12 | 13 | 21 | 47 | 53 | 100 |
| Total | 65 | 11 | 14 | 10 | 19 | 12 | 15 | 19 | 46 | 54 | 100 |
The Committee’s and the sample ranking of technologies evaluated by the 2006/7 Basket Committee (monthly cost threshold = 125 NIS)
| Technology | Committee’s inclusion decision | Rank Basket Committee | Rank survey - Total | Rank survey - Physicians | Rank survey - Members of any Basket Committee | Rank efficiencya |
|---|---|---|---|---|---|---|
| Crestor Ezetrol | YES | 1 | 18 | 18 | 15 | 12 |
| Atacand Ocsaar Diovan Olmetec | YES | 2 | 29 | 29 | 25 | 3 |
| Lantus Levemir | YES | 3 | 29 | 29 | 25 | 5 |
| Apidra Humalog Novorapid | YES | 4 | 29 | 29 | 25 | 9 |
| Eloxatin | YES | 5 | 15 | 15 | 15 | 4 |
| Xeloda | YES | 6 | 15 | 15 | 15 | 1 |
| Herceptin | YES | 7 | 11 | 11 | 12 | 23 |
| Hepsera | YES | 8 | 3 | 3 | 3 | 16 |
| Viread | YES | 9 | 9 | 8 | 7 | 22 |
| Prevnar | YES | 10 | 33 | 33 | 33 | 32 |
| Mabthera | YES | 11 | 1 | 1 | 1 | 14 |
| Keppra | YES | 12 | 21 | 21 | 24 | 28 |
| Zyprexa | YES | 13 | 22 | 22 | 22 | 6 |
| Exjade | YES | 14 | 5 | 4 | 4 | 19 |
| Plavix (cardiac) | YES | 15 | 8 | 8 | 5 | 10 |
| Growth hormon | YES | 16 | 14 | 14 | 11 | 13 |
| Plavix (stroke) | YES | 17 | 1 | 1 | 1 | 8 |
| Velcade | YES | 18 | 4 | 5 | 5 | 27 |
| Zomera | NO | 26.5 | 11 | 11 | 12 | 29 |
| Apo-Go | NO | 26.5 | 6 | 6 | 9 | 21 |
| Azilect | NO | 26.5 | 6 | 6 | 9 | 17 |
| Cetuximab (Erbitux®) | NO | 26.5 | 25 | 24 | 25 | 31 |
| Doxil | NO | 26.5 | 15 | 15 | 15 | 11 |
| Emend | NO | 26.5 | 25 | 24 | 25 | 33 |
| Erlotinib (Tarceva®) | NO | 26.5 | 25 | 24 | 25 | 30 |
| Faslodex | NO | 26.5 | 11 | 11 | 12 | 24 |
| Forteo | NO | 26.5 | 28 | 28 | 25 | 34 |
| Gardasil | NO | 26.5 | 9 | 8 | 7 | 20 |
| Lucentis | NO | 26.5 | 18 | 18 | 15 | 18 |
| Rimonabant (Acomplia®) | NO | 26.5 | 34 | 34 | 34 | 25 |
| Sifrol | NO | 26.5 | 20 | 20 | 21 | 26 |
| Spiriva | NO | 26.5 | 29 | 29 | 25 | 7 |
| Zemplar | NO | 26.5 | 22 | 22 | 22 | 15 |
| Zyban | NO | 26.5 | 24 | 27 | 20 | 2 |
| Mean rank | YES | 9.5 | 14.8 | 16.9 | 16.1 | 14.0 |
| NO | 26.5 | 19.3 | 19.2 | 18.8 | 21.4 |
aBy international data on cost per QALY gained
The Committee’s and the sample ranking of technologies evaluated by the 2006/7 Basket Committee (monthly cost threshold = 250 NIS)
| Technology | Committee’s inclusion decision | Rank Basket Committee | Rank survey - Total | Rank survey - Physicians | Rank survey - Members of any Basket Committee | Rank efficiencya |
|---|---|---|---|---|---|---|
| Crestor Ezetrol | YES | 1 | 28 | 28 | 25 | 12 |
| Atacand Ocsaar Diovan Olmetec | YES | 2 | 28 | 28 | 25 | 3 |
| Lantus Levemir | YES | 3 | 17 | 17 | 14 | 5 |
| Apidra Humalog Novorapid | YES | 4 | 28 | 28 | 25 | 9 |
| Eloxatin | YES | 5 | 14 | 14 | 14 | 4 |
| Xeloda | YES | 6 | 14 | 14 | 14 | 1 |
| Herceptin | YES | 7 | 10 | 10 | 11 | 23 |
| Hepsera | YES | 8 | 2 | 2 | 2 | 16 |
| Viread | YES | 9 | 9 | 7 | 7 | 22 |
| Prevnar | YES | 10 | 32 | 32 | 32 | 32 |
| Mabthera | YES | 11 | 1 | 1 | 1 | 14 |
| Keppra | YES | 12 | 20 | 20 | 24 | 28 |
| Zyprexa | YES | 13 | 21 | 21 | 22 | 6 |
| Exjade | YES | 14 | 4 | 4 | 3 | 19 |
| Plavix (cardiac) | YES | 15 | 7 | 7 | 4 | 10 |
| Growth hormon | YES | 16 | 13 | 13 | 10 | 13 |
| Plavix (stroke) | YES | 17 | 7 | 7 | 4 | 8 |
| Velcade | YES | 18 | 3 | 3 | 4 | 27 |
| Zomera | NO | 26.5 | 10 | 10 | 11 | 29 |
| Apo-Go | NO | 26.5 | 5 | 5 | 8 | 21 |
| Azilect | NO | 26.5 | 5 | 5 | 8 | 17 |
| Cetuximab (Erbitux®) | NO | 26.5 | 25 | 25 | 25 | 31 |
| Doxil | NO | 26.5 | 14 | 14 | 14 | 11 |
| Emend | NO | 26.5 | 33 | 33 | 33 | 33 |
| Erlotinib (Tarceva®) | NO | 26.5 | 25 | 25 | 25 | 30 |
| Faslodex | NO | 26.5 | 10 | 10 | 11 | 24 |
| Forteo | NO | 26.5 | 27 | 27 | 25 | 34 |
| Gardasil | NO | 26.5 | 23 | 23 | 19 | 20 |
| Lucentis | NO | 26.5 | 17 | 17 | 14 | 18 |
| Rimonabant (Acomplia®) | NO | 26.5 | 34 | 34 | 34 | 25 |
| Sifrol | NO | 26.5 | 19 | 19 | 21 | 26 |
| Spiriva | NO | 26.5 | 28 | 28 | 25 | 7 |
| Zemplar | NO | 26.5 | 21 | 21 | 22 | 15 |
| Zyban | NO | 26.5 | 23 | 23 | 19 | 2 |
| Mean rank | YES | 9.5 | 14.3 | 14.2 | 13.4 | 14.0 |
| NO | 26.5 | 19.9 | 19.9 | 19.6 | 21.4 |
aBy international data on cost per QALY gained
The Committee’s and the sample ranking of technologies accepted by the 2006/7 Basket Committee (monthly cost threshold = 125 NIS)
| Technology | Rank Basket Committee | Diagonal | Rank survey - Total | Rank survey - Physicians | Rank survey - Members of the Basket Committee | Rank efficiencya |
|---|---|---|---|---|---|---|
| Crestor Ezetrol | 1 | 1 | 12 | 12 | 10 | 9 |
| Atacand Ocsaar Diovan Olmetec | 2 | 2 | 15 | 15 | 15 | 2 |
| Lantus Levemir | 3 | 3 | 15 | 15 | 15 | 4 |
| Apidra Humalog Novorapid | 4 | 4 | 15 | 15 | 15 | 7 |
| Eloxatin | 5 | 5 | 10 | 10 | 10 | 3 |
| Xeloda | 6 | 6 | 10 | 10 | 10 | 1 |
| Herceptin | 7 | 7 | 8 | 8 | 9 | 15 |
| Hepsera | 8 | 8 | 3 | 3 | 3 | 12 |
| Viread | 9 | 9 | 7 | 6 | 7 | 14 |
| Prevnar | 10 | 10 | 18 | 18 | 18 | 18 |
| Mabthera | 11 | 11 | 1 | 1 | 1 | 11 |
| Keppra | 12 | 12 | 13 | 13 | 14 | 5 |
| Zyprexa | 13 | 13 | 14 | 14 | 13 | 17 |
| Exjade | 14 | 14 | 5 | 4 | 4 | 13 |
| Plavix (cardiac) | 15 | 15 | 6 | 6 | 5 | 8 |
| Growth hormon | 16 | 16 | 9 | 9 | 8 | 10 |
| Plavix (stroke) | 17 | 17 | 1 | 1 | 1 | 6 |
| Velcade | 18 | 18 | 4 | 5 | 5 | 16 |
aBy international data on cost per QALY gained
The Committee’s and the sample ranking of technologies accepted by the 2006/7 Basket Committee (monthly cost threshold = 250 NIS)
| Technology | Rank Basket Committee | Diagonal | Rank survey - Total | Rank survey - Physicians | Rank survey - Members of the Basket Committee | Rank efficiencya |
|---|---|---|---|---|---|---|
| Crestor Ezetrol | 1 | 1 | 15 | 15 | 15 | 9 |
| Atacand Ocsaar Diovan Olmetec | 2 | 2 | 15 | 15 | 15 | 2 |
| Lantus Levemir | 3 | 3 | 12 | 12 | 10 | 4 |
| Apidra Humalog Novorapid | 4 | 4 | 15 | 15 | 15 | 7 |
| Eloxatin | 5 | 5 | 10 | 10 | 10 | 3 |
| Xeloda | 6 | 6 | 10 | 10 | 10 | 1 |
| Herceptin | 7 | 7 | 8 | 8 | 9 | 15 |
| Hepsera | 8 | 8 | 2 | 2 | 2 | 12 |
| Viread | 9 | 9 | 7 | 5 | 7 | 14 |
| Prevnar | 10 | 10 | 18 | 18 | 18 | 18 |
| Mabthera | 11 | 11 | 1 | 1 | 1 | 11 |
| Keppra | 12 | 12 | 13 | 13 | 14 | 5 |
| Zyprexa | 13 | 13 | 14 | 14 | 13 | 17 |
| Exjade | 14 | 14 | 4 | 3 | 3 | 13 |
| Plavix (cardiac) | 15 | 15 | 5 | 5 | 4 | 8 |
| Growth hormon | 16 | 16 | 9 | 9 | 8 | 10 |
| Plavix (stroke) | 17 | 17 | 5 | 5 | 4 | 6 |
| Velcade | 18 | 18 | 3 | 4 | 4 | 16 |
aBy international data on cost per QALY gained
Correlations among the different rankings: all technologies, monthly cost threshold = 125 and 250 NIS
| Rank Basket Committeea | Rank survey - Total | Rank survey - Physicians | Rank survey - Members of the Basket Committee | Rank efficiency | |
|---|---|---|---|---|---|
| Monthly cost threshold = 125 NIS | |||||
| Correlation with the Committee’s ranking - All technologies (survey: 1–34, Committee: NO = 26.5) | 1.000 | 0.035 | 0.036 | 0.096 | 0.450a |
| Correlation with the Efficiency ranking - All technologies (survey: 1–34, Committee: NO = 26.5) | 0.450a | 0.067 | 0.040 | 0.176 | 1.000 |
| Monthly cost threshold = 250 NIS | |||||
| Correlation with the Committee’s ranking - All technologies (survey: 1–34, Committee: NO = 26.5) | 1.000 | 0.101 | 0.106 | 0.150 | 0.450a |
| Correlation with the Efficiency ranking - All technologies (survey: 1–34, Committee: NO = 26.5) | 0.450a | 0.136 | 0.132 | 0.241 | 1.000 |
aSignificant at 0.05
Correlations among the different rankings: accepted technologies, monthly cost threshold = 125 and 250 NIS
| Rank Basket Committeea | Rank survey - Total | Rank survey - Physicians | Rank survey - Members of the Basket Committee | Rank efficiency | |
|---|---|---|---|---|---|
| Monthly cost threshold = 125 NIS | |||||
| Correlation with the Committee’s ranking - Accepted technologies (survey:1–18) | 1.000 | −0.541a | −0.528a | −0.529a | 0.434a |
| Correlation with the Efficiency ranking - Accepted technologies (survey: 1–18) | 0.434b | −0.146 | −0.149 | −0.150 | 1.000 |
| Monthly cost threshold = 250 NIS | |||||
| Correlation with the Committee’s ranking - Accepted technologies (survey:1–18) | 1.000 | −0.530a | −0.513a | −0.537a | 0.434b |
| Correlation with the Efficiency ranking - Accepted technologies (survey: 1–18) | 0.434b | −0.169 | −0.179 | −0.142 | 1.000 |
aSignificant at 0.05
bsignificant at 0.10
Fig. 1The Committee’s, survey and efficiency rankings of the accepted technologies