| Literature DB >> 28469090 |
W Taylor Kimberly1, John F O'Sullivan2, Anjali K Nath3, Michelle Keyes4, Xu Shi2, Martin G Larson4,5, Qiong Yang4,5, Michelle T Long4,6, Ramachandran Vasan4, Randall T Peterson3, Thomas J Wang7, Kathleen E Corey8, Robert E Gerszten2.
Abstract
The discovery of metabolite-phenotype associations may highlight candidate biomarkers and metabolic pathways altered in disease states. We sought to identify novel metabolites associated with obesity and one of its major complications, nonalcoholic fatty liver disease (NAFLD), using a liquid chromatography-tandem mass spectrometry method. In 997 individuals in Framingham Heart Study Generation 3 (FHS Gen 3), we identified an association between anandamide (AEA) and BMI. Further examination revealed that AEA was associated with radiographic hepatic steatosis. In a histologically defined NAFLD cohort, AEA was associated with NAFLD severity, the presence of nonalcoholic steatohepatitis, and fibrosis. These data highlight AEA as a marker linking cardiometabolic disease and NAFLD severity.Entities:
Keywords: Gastroenterology; Metabolism
Year: 2017 PMID： 28469090 PMCID： PMC5414569 DOI： 10.1172/jci.insight.92989
Source DB: PubMed Journal: JCI Insight ISSN： 2379-3708