Beriwan Ezat1, Lasse Pihlstrøm2, Jan Aasly3, Ole-Bjørn Tysnes4, Arild Egge5, Espen Dietrichs6. 1. Nevrologisk avdeling Oslo universitetssykehus og Det medisinske fakultet Universitetet i Oslo. 2. Nevrologisk avdeling Oslo universitetssykehus og Universitetet i Oslo. 3. Avdeling for nevrologi og klinisk nevrofysiologi St. Olavs hospital og Norges teknisk-naturvitenskapelige universitet. 4. Nevrologisk avdeling Haukeland universitetssykehus og Klinisk institutt 1 Universitetet i Bergen. 5. Nevrokirurgisk avdeling Oslo universitetssykehus. 6. Nevrologisk avdeling Oslo universitetssykehus og Institutt for klinisk medisin Universitetet i Oslo.
Abstract
BACKGROUND: Many patients with Parkinson’s disease with severe motor fluctuations benefit from advanced therapies – either deep brain stimulation or continuous infusion therapy with levodopa-carbidopa intestinal gel or apomorphine. In Norway, deep brain stimulation is provided as a shared national or multi-regional service. The treatment is currently available at Oslo University Hospital and St. Olavs Hospital; prior to 2012 it was also available at Haukeland University Hospital. Infusion therapy has no similar geographical restrictions. We therefore wished to examine geographical differences in the use of the two most common forms of advanced therapy for Parkinson’s disease. MATERIAL AND METHOD: The county of residence of all patients receiving deep brain stimulation or infusion therapy with levodopa-carbidopa intestinal gel in the period 2009 – 2013 was recorded using data from hospital episode statistics and the Norwegian Prescription Database, respectively. RESULTS: A total of 262 patients with Parkinson’s disease began advanced therapy, 146 with deep brain stimulation and 116 with levodopa-carbidopa infusion. Four counties differed significantly from the others in their use of the two methods. Møre og Romsdal, Nordland and Sør-Trøndelag treated a significantly greater proportion of patients with deep brain stimulation, while Rogaland treated a significantly greater proportion with levodopa-carbidopa infusion therapy. INTERPRETATION: Advanced therapies for Parkinson’s disease are offered throughout Norway, but there are significant geographical differences in the type of therapy initiated. One possible explanation is that patients in different counties receive different information about the therapeutic options available.
BACKGROUND: Many patients with Parkinson’s disease with severe motor fluctuations benefit from advanced therapies – either deep brain stimulation or continuous infusion therapy with levodopa-carbidopa intestinal gel or apomorphine. In Norway, deep brain stimulation is provided as a shared national or multi-regional service. The treatment is currently available at Oslo University Hospital and St. Olavs Hospital; prior to 2012 it was also available at Haukeland University Hospital. Infusion therapy has no similar geographical restrictions. We therefore wished to examine geographical differences in the use of the two most common forms of advanced therapy for Parkinson’s disease. MATERIAL AND METHOD: The county of residence of all patients receiving deep brain stimulation or infusion therapy with levodopa-carbidopa intestinal gel in the period 2009 – 2013 was recorded using data from hospital episode statistics and the Norwegian Prescription Database, respectively. RESULTS: A total of 262 patients with Parkinson’s disease began advanced therapy, 146 with deep brain stimulation and 116 with levodopa-carbidopa infusion. Four counties differed significantly from the others in their use of the two methods. Møre og Romsdal, Nordland and Sør-Trøndelag treated a significantly greater proportion of patients with deep brain stimulation, while Rogaland treated a significantly greater proportion with levodopa-carbidopa infusion therapy. INTERPRETATION: Advanced therapies for Parkinson’s disease are offered throughout Norway, but there are significant geographical differences in the type of therapy initiated. One possible explanation is that patients in different counties receive different information about the therapeutic options available.
Authors: József Attila Szász; Viorelia Adelina Constantin; Károly Orbán-Kis; Ligia Ariana Bancu; Simona Maria Bataga; Marius Ciorba; Előd Nagy; Mircea Radu Neagoe; István Mihály; Róbert Máté Szász; Krisztina Kelemen; Mihaela Simu; Szabolcs Szatmári Journal: Pharmaceutics Date: 2022-05-24 Impact factor: 6.525
Authors: Tove Henriksen; Kim Peder Dalhoff; Henriette Engel Hansen; Andreas W Brenneche; Ulla Sofie Lønberg; Erik Hvid Danielsen Journal: Mov Disord Clin Pract Date: 2020-07-02