Literature DB >> 28467922

Metabolic Flexibility in Health and Disease.

Bret H Goodpaster1, Lauren M Sparks2.   

Abstract

Metabolic flexibility is the ability to respond or adapt to conditional changes in metabolic demand. This broad concept has been propagated to explain insulin resistance and mechanisms governing fuel selection between glucose and fatty acids, highlighting the metabolic inflexibility of obesity and type 2 diabetes. In parallel, contemporary exercise physiology research has helped to identify potential mechanisms underlying altered fuel metabolism in obesity and diabetes. Advances in "omics" technologies have further stimulated additional basic and clinical-translational research to further interrogate mechanisms for improved metabolic flexibility in skeletal muscle and adipose tissue with the goal of preventing and treating metabolic disease.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  adipose tissue; exercise; insulin resistance; metabolic flexibility; obesity; skeletal muscle; type 2 diabetes

Mesh：

Substances：

Year:  2017        PMID： 28467922      PMCID： PMC5513193          DOI： 10.1016/j.cmet.2017.04.015

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  121 in total

1.  The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome.

Authors:  Kitt Falk Petersen; Sylvie Dufour; David B Savage; Stefan Bilz; Gina Solomon; Shin Yonemitsu; Gary W Cline; Douglas Befroy; Laura Zemany; Barbara B Kahn; Xenophon Papademetris; Douglas L Rothman; Gerald I Shulman
Journal:  Proc Natl Acad Sci U S A       Date:  2007-07-18       Impact factor: 11.205

2.  Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor.

Authors:  Barbara Ukropcova; Michele McNeil; Olga Sereda; Lilian de Jonge; Hui Xie; George A Bray; Steven R Smith
Journal:  J Clin Invest       Date:  2005-07       Impact factor: 14.808

Review 3.  The metabolic syndrome.

Authors:  Robert H Eckel; Scott M Grundy; Paul Z Zimmet
Journal:  Lancet       Date:  2005 Apr 16-22       Impact factor: 79.321

4.  Effect of exercise-diet manipulation on muscle glycogen and its subsequent utilization during performance.

Authors:  W M Sherman; D L Costill; W J Fink; J M Miller
Journal:  Int J Sports Med       Date:  1981-05       Impact factor: 3.118

5.  Clinical trial demonstrates exercise following bariatric surgery improves insulin sensitivity.

Authors:  Paul M Coen; Charles J Tanner; Nicole L Helbling; Gabriel S Dubis; Kazanna C Hames; Hui Xie; George M Eid; Maja Stefanovic-Racic; Frederico G S Toledo; John M Jakicic; Joseph A Houmard; Bret H Goodpaster
Journal:  J Clin Invest       Date:  2014-12-01       Impact factor: 14.808

6.  Role of the sympathoadrenergic system in adipose tissue metabolism during exercise in humans.

Authors:  B Stallknecht; J Lorentsen; L H Enevoldsen; J Bülow; F Biering-Sørensen; H Galbo; M Kjaer
Journal:  J Physiol       Date:  2001-10-01       Impact factor: 5.182

7.  Stimulation of lipolysis in humans by physiological hypercortisolemia.

Authors:  G D Divertie; M D Jensen; J M Miles
Journal:  Diabetes       Date:  1991-10       Impact factor: 9.461

8.  Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes.

Authors:  S O'Rahilly; R C Turner; D R Matthews
Journal:  N Engl J Med       Date:  1988-05-12       Impact factor: 91.245

9.  Downregulation of adipose tissue fatty acid trafficking in obesity: a driver for ectopic fat deposition?

Authors:  Siobhán E McQuaid; Leanne Hodson; Matthew J Neville; A Louise Dennis; Jane Cheeseman; Sandy M Humphreys; Toralph Ruge; Marjorie Gilbert; Barbara A Fielding; Keith N Frayn; Fredrik Karpe
Journal:  Diabetes       Date:  2010-10-13       Impact factor: 9.461

10.  Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression.

Authors:  Balkrishna Chaube; Parmanand Malvi; Shivendra Vikram Singh; Naoshad Mohammad; Avtar Singh Meena; Manoj Kumar Bhat
Journal:  Oncotarget       Date:  2015-11-10
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  227 in total

1.  Noninvasive evaluation of fat-carbohydrate metabolic switching in heart and contracting skeletal muscle.

Authors:  Timothy R DeGrado; Mukesh K Pandey; Anthony P Belanger; Falguni Basuli; Aditya Bansal; Shuyan Wang
Journal:  Am J Physiol Endocrinol Metab       Date:  2018-12-04       Impact factor: 4.310

2.  Macronutrient, Energy, and Bile Acid Metabolism Pathways Altered Following a Physiological Meal Challenge, Relative to Fasting, among Guatemalan Adults.

Authors:  Elaine A Yu; Tianwei Yu; Dean P Jones; Reynaldo Martorell; Manuel Ramirez-Zea; Aryeh D Stein
Journal:  J Nutr       Date:  2020-08-01       Impact factor: 4.798

Review 3.  Exercise and metabolic health: beyond skeletal muscle.

Authors:  John P Thyfault; Audrey Bergouignan
Journal:  Diabetologia       Date:  2020-06-11       Impact factor: 10.122

4.  Exercise and Testosterone Countermeasures to Mitigate Metabolic Changes during Bed Rest.

Authors:  Meghan E Downs; Jessica M Scott; Lori L Ploutz-Snyder; Robert Ploutz-Snyder; Elizabeth Goetchius; Roxanne E Buxton; Christopher P Danesi; Kathleen M Randolph; Randall J Urban; Melinda Sheffield-Moore; E Lichar Dillon
Journal:  Life Sci Space Res (Amst)       Date:  2020-05-20

5.  A multi-sensor system for measuring bovine embryo metabolism.

Authors:  Yusra Obeidat; Giovana Catandi; Elaine Carnevale; Adam J Chicco; August DeMann; Stuart Field; Tom Chen
Journal:  Biosens Bioelectron       Date:  2018-09-21       Impact factor: 10.618

6.  Effects of high-fat diet and AMP-activated protein kinase modulation on the regulation of whole-body lipid metabolism.

Authors:  Milena Schönke; Julie Massart; Juleen R Zierath
Journal:  J Lipid Res       Date:  2018-05-08       Impact factor: 5.922

7.  Short-Term Diabetes Remission Outcomes in Patients with BMI ≤ 30 kg/m2 Following Sleeve Gastrectomy.

Authors:  Jason Widjaja; Haixing Pan; Ponnie Robertlee Dolo; Libin Yao; Chao Li; Yong Shao; Xiaocheng Zhu
Journal:  Obes Surg       Date:  2020-01       Impact factor: 4.129

8.  Plasma fatty acids in de novo lipogenesis pathway are associated with diabetogenic indicators among adults: NHANES 2003-2004.

Authors:  Elaine A Yu; Peter J Hu; Saurabh Mehta
Journal:  Am J Clin Nutr       Date:  2018-09-01       Impact factor: 7.045

Review 9.  Mitochondria, OxPhos, and neurodegeneration: cells are not just running out of gas.

Authors:  Estela Area-Gomez; Cristina Guardia-Laguarta; Eric A Schon; Serge Przedborski
Journal:  J Clin Invest       Date:  2019-01-02       Impact factor: 14.808

Review 10.  Cellular Metabolism in Lung Health and Disease.

Authors:  Gang Liu; Ross Summer
Journal:  Annu Rev Physiol       Date:  2018-11-28       Impact factor: 19.318
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