Literature DB >> 28467871

A Highly Durable RNAi Therapeutic Inhibitor of PCSK9.

Kevin Fitzgerald1,2, David Kallend3, Amy Simon1.   

Abstract

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Year:  2017        PMID： 28467871     DOI： 10.1056/NEJMc1703361

Source DB:  PubMed          Journal:  N Engl J Med        ISSN： 0028-4793            Impact factor:   91.245


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  10 in total

1.  Efficient Gene Silencing in Brain Tumors with Hydrophobically Modified siRNAs.

Authors:  Maire F Osborn; Andrew H Coles; Diane Golebiowski; Dimas Echeverria; Michael P Moazami; Jonathan K Watts; Miguel Sena-Esteves; Anastasia Khvorova
Journal:  Mol Cancer Ther       Date:  2018-04-13       Impact factor: 6.261

Review 2.  An RNA toolbox for cancer immunotherapy.

Authors:  Fernando Pastor; Pedro Berraondo; Iñaki Etxeberria; Josh Frederick; Ugur Sahin; Eli Gilboa; Ignacio Melero
Journal:  Nat Rev Drug Discov       Date:  2018-09-07       Impact factor: 84.694

3.  RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models.

Authors:  Nadine Haase; Donald J Foster; Mark W Cunningham; Julia Bercher; Tuyen Nguyen; Svetlana Shulga-Morskaya; Stuart Milstein; Sarfraz Shaikh; Jeff Rollins; Michaela Golic; Florian Herse; Kristin Kräker; Ivo Bendix; Meray Serdar; Hanna Napieczynska; Arnd Heuser; Alexandra Gellhaus; Kristin Thiele; Gerd Wallukat; Dominik N Müller; Babbette LaMarca; Ralf Dechend
Journal:  J Clin Invest       Date:  2020-06-01       Impact factor: 14.808

4.  Safety evaluation of 2'-deoxy-2'-fluoro nucleotides in GalNAc-siRNA conjugates.

Authors:  Maja M Janas; Ivan Zlatev; Ju Liu; Yongfeng Jiang; Scott A Barros; Jessica E Sutherland; Wendell P Davis; Jingxuan Liu; Christopher R Brown; Xiumin Liu; Mark K Schlegel; Lauren Blair; Xuemei Zhang; Biplab Das; Chris Tran; Krishna Aluri; Jing Li; Saket Agarwal; Ramesh Indrakanti; Klaus Charisse; Jayaprakash Nair; Shigeo Matsuda; Kallanthottathil G Rajeev; Tracy Zimmermann; Laura Sepp-Lorenzino; Yuanxin Xu; Akin Akinc; Kevin Fitzgerald; Akshay K Vaishnaw; Peter F Smith; Muthiah Manoharan; Vasant Jadhav; Jing-Tao Wu; Martin A Maier
Journal:  Nucleic Acids Res       Date:  2019-04-23       Impact factor: 16.971

Review 5.  Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials.

Authors:  Yuncong Shi; Huanji Zhang; Suli Huang; Li Yin; Feng Wang; Pei Luo; Hui Huang
Journal:  Signal Transduct Target Ther       Date:  2022-06-25

6.  Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing.

Authors:  Hartmut Jahns; Rohan Degaonkar; Peter Podbevsek; Swati Gupta; Anna Bisbe; Krishna Aluri; John Szeto; Pawan Kumar; Sarah LeBlanc; Tim Racie; Christopher R Brown; Adam Castoreno; Dale C Guenther; Vasant Jadhav; Martin A Maier; Janez Plavec; Martin Egli; Muthiah Manoharan; Ivan Zlatev
Journal:  Nucleic Acids Res       Date:  2021-10-11       Impact factor: 16.971

7.  RNA interference efficiently targets human leukemia driven by a fusion oncogene in vivo.

Authors:  N Jyotsana; A Sharma; A Chaturvedi; M Scherr; F Kuchenbauer; L Sajti; A Barchanski; R Lindner; F Noyan; K-W Sühs; D Grote-Koska; K Brand; H-P Vornlocher; M Stanulla; B Bornhauser; J-P Bourquin; M Eder; F Thol; A Ganser; R K Humphries; E Ramsay; P Cullis; M Heuser
Journal:  Leukemia       Date:  2017-08-22       Impact factor: 11.528

Review 8.  The Nonclinical Safety Profile of GalNAc-conjugated RNAi Therapeutics in Subacute Studies.

Authors:  Maja M Janas; Carole E Harbison; Victoria K Perry; Brenda Carito; Jessica E Sutherland; Akshay K Vaishnaw; Natalie D Keirstead; Garvin Warner
Journal:  Toxicol Pathol       Date:  2018-08-23       Impact factor: 1.902

9.  An investigational RNAi therapeutic targeting Factor XII (ALN-F12) for the treatment of hereditary angioedema.

Authors:  Jingxuan Liu; June Qin; Anna Borodovsky; Timothy Racie; Adam Castoreno; Mark Schlegel; Martin A Maier; Tracy Zimmerman; Kevin Fitzgerald; James Butler; Akin Akinc
Journal:  RNA       Date:  2018-11-21       Impact factor: 4.942

10.  In vivo genome and base editing of a human PCSK9 knock-in hypercholesterolemic mouse model.

Authors:  Alba Carreras; Luna Simona Pane; Roberto Nitsch; Katja Madeyski-Bengtson; Michelle Porritt; Pinar Akcakaya; Amir Taheri-Ghahfarokhi; Elke Ericson; Mikael Bjursell; Marta Perez-Alcazar; Frank Seeliger; Magnus Althage; Ralph Knöll; Ryan Hicks; Lorenz M Mayr; Rosie Perkins; Daniel Lindén; Jan Borén; Mohammad Bohlooly-Y; Marcello Maresca
Journal:  BMC Biol       Date:  2019-01-15       Impact factor: 7.431
  10 in total

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