| Literature DB >> 28467690 |
Yannan Yang1, Yao Lu1,2, Prasanna Lakshmi Abbaraju1, Jun Zhang1, Min Zhang1, Guangya Xiang2, Chengzhong Yu1.
Abstract
Developing potent adjuvants for the stimulation of robust immune response is central for effective cancer immunotherapy. Double-shelled dendritic mesoporous organosilica hollow spheres are an excellent adjuvant and provide superior immunity in cancer immunotherapy, and better than their counterparts either with a pure silica composition or a single-walled architecture. This study provides new insights in the rational design of effective nanostructured adjuvants for vaccine developments.Entities:
Keywords: adjuvants; antitumor activity; immunotherapy; multi-shelled materials; organosilica
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Year: 2017 PMID: 28467690 DOI: 10.1002/anie.201701550
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN: 1433-7851 Impact factor: 15.336