Literature DB >> 2846751

Oxygen-dependent killing of Staphylococcus aureus by human neutrophils.

S W Edwards1, J E Say, C A Hart.   

Abstract

Luminol-dependent chemiluminescence was used as a monitor of reactive oxidant generation during phagocytosis of Staphylococcus aureus by human neutrophils. Reactive oxidants play a crucial role in the killing of this organism because: (a) S. aureus was killed most rapidly when the rate of increase of chemiluminescence was greatest; (b) neutrophils which had been activated to generate reactive oxidants by re-aeration of anaerobic suspensions killed this bacterium more efficiently than control suspensions; and (c) neutrophils from a patient with chronic granulomatous disease could neither generate reactive oxidants nor kill S. aureus.

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Year:  1987        PMID： 2846751     DOI： 10.1099/00221287-133-12-3591

Source DB:  PubMed          Journal:  J Gen Microbiol        ISSN： 0022-1287


  14 in total

1.  Neutrophils from the synovial fluid of patients with rheumatoid arthritis express the high affinity immunoglobulin G receptor, Fc gamma RI (CD64): role of immune complexes and cytokines in induction of receptor expression.

Authors:  J A Quayle; F Watson; R C Bucknall; S W Edwards
Journal:  Immunology       Date:  1997-06       Impact factor: 7.397

2.  PRAM-1 is required for optimal integrin-dependent neutrophil function.

Authors:  Regina A Clemens; Sally A Newbrough; Elaine Y Chung; Shereen Gheith; Andrew L Singer; Gary A Koretzky; Erik J Peterson
Journal:  Mol Cell Biol       Date:  2004-12       Impact factor: 4.272

3.  Activation of the neutrophil myeloperoxidase-H2O2 system by synovial fluid isolated from patients with rheumatoid arthritis.

Authors:  H L Nurcombe; R C Bucknall; S W Edwards
Journal:  Ann Rheum Dis       Date:  1991-04       Impact factor: 19.103

4.  Potentiation of the respiratory burst of human neutrophils by cycloheximide: regulation of reactive oxidant production by a protein(s) with rapid turnover?

Authors:  R E Stringer; S W Edwards
Journal:  Inflamm Res       Date:  1995-04       Impact factor: 4.575

5.  Neutrophils isolated from the synovial fluid of patients with rheumatoid arthritis: priming and activation in vivo.

Authors:  H L Nurcombe; R C Bucknall; S W Edwards
Journal:  Ann Rheum Dis       Date:  1991-03       Impact factor: 19.103

6.  Receptor expression in synovial fluid neutrophils from patients with rheumatoid arthritis.

Authors:  F Watson; J J Robinson; M Phelan; R C Bucknall; S W Edwards
Journal:  Ann Rheum Dis       Date:  1993-05       Impact factor: 19.103

7.  Activation of neutrophils by soluble and insoluble immunoglobulin aggregates from synovial fluid of patients with rheumatoid arthritis.

Authors:  J J Robinson; F Watson; M Phelan; R C Bucknall; S W Edwards
Journal:  Ann Rheum Dis       Date:  1993-05       Impact factor: 19.103

8.  Activation of neutrophil reactive-oxidant production by synovial fluid from patients with inflammatory joint disease. Soluble and insoluble immunoglobulin aggregates activate different pathways in primed and unprimed cells.

Authors:  J Robinson; F Watson; R C Bucknall; S W Edwards
Journal:  Biochem J       Date:  1992-09-01       Impact factor: 3.857

9.  Role of Fc gamma receptors in the activation of neutrophils by soluble and insoluble immunoglobulin aggregates isolated from the synovial fluid of patients with rheumatoid arthritis.

Authors:  J J Robinson; F Watson; R C Bucknall; S W Edwards
Journal:  Ann Rheum Dis       Date:  1994-08       Impact factor: 19.103

10.  Inhibition of neutrophil oxidant secretion by D-penicillamine: scavenging of H2O2 and HOCl.

Authors:  M J Ledson; R C Bucknall; S W Edwards
Journal:  Ann Rheum Dis       Date:  1992-03       Impact factor: 19.103
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