Dear Sir,We read with great interest the case report from Gibelli and Biasi[1] who define persistent left superior vena cava (PSLVC) not only as an anatomical variant. Actually, we agree with the authors especially in consideration of the huge number of cardiac invasive procedures in everyday clinical practice.However, we would like to stress the concept, as we previously did,[2] that the complete workup should start beginning with a cardiac ultrasound examination enhanced with agitated saline contrast. The authors do mention this technique in the paper, but there is no trace of such examination in the case report. Even though the sensitivity and ultimately the reliability of cardiac magnetic resonance imaging (MRI) may be of paramount importance in the diagnosis of PLSVC, cardiac ultrasound is obviously easy, widely available, cost-effective, and highly sustainable in the very dark scenario grinding on the Italian health system. Additionally, we favor transesophageal echocardiography in our stepwise approach before heading to cardiac MRI to avoid Gadolinium-contrast exposure.In conclusion, we support the authors’ firm statement that the absence of the right superior vena cava should be looked after when PLSVC is identified; on the contrary, we prefer to follow a noninvasive workup protocol which consistently shares comparable diagnostic features of MRI when examining the venae cavae.