Doran Drew1, Adrian Baranchuk2, Wilma Hopman3, Robert J Brison4. 1. Department of Medicine, Cardiology Division, Kingston General Hospital, Queen's University, Kingston, Ontario, Canada; Department of Emergency Medicine, Kingston General Hospital, Queen's University, Kingston, Ontario, Canada. 2. Department of Medicine, Cardiology Division, Kingston General Hospital, Queen's University, Kingston, Ontario, Canada. Electronic address: barancha@kgh.kari.net. 3. Department of Medicine, Cardiology Division, Kingston General Hospital, Queen's University, Kingston, Ontario, Canada. 4. Department of Emergency Medicine, Kingston General Hospital, Queen's University, Kingston, Ontario, Canada.
Abstract
AIMS: We were interested in the impact of fever on the QT interval as information on this subject is limited. METHODS: We performed a retrospective, single centre study over a two year period, ending December 31st, 2013. Participants were identified using an electronic chart review of emergency department records linked to an ECG data base. Study subjects were drawn from patients presenting with fever to an academic emergency department in Canada. Our study identified febrile (T>38.0°C) patients aged >18years presenting to our centre. Included participants must have had an ED based ECG at the time of presentation with fever and a comparison ECG performed within 30days and without fever. Actively paced patients were excluded. QT values were corrected using Bazett's, Fridericia's and The Framingham Formula. QT values for febrile and afebrile cohorts were compared using Related-Samples Wilcoxon Signed Rank Test. RESULTS: 181 patients satisfied our inclusion/exclusion criteria, 54.1% were female and mean age was 68.9years old. Mean duration between febrile and afebrile ECGs was 6.1days. The median corrected QT interval (QTc) was significantly shorter in patients during their febrile presentation, as compared to their afebrile presentation when correcting for QT using both Framingham [QTc=466.1ms (445.8-499.5) vs. 507.6 (476.0-539.0); p<0.001] and Fridericia's formula [QTc=388.7ms, (371.5-407.5) vs. 406.7ms, (386.1-434.4); p<0.001]. This difference was independent of gender. CONCLUSION: We found fever to shorten the QTc independently of sex in a general emergency department population.
AIMS: We were interested in the impact of fever on the QT interval as information on this subject is limited. METHODS: We performed a retrospective, single centre study over a two year period, ending December 31st, 2013. Participants were identified using an electronic chart review of emergency department records linked to an ECG data base. Study subjects were drawn from patients presenting with fever to an academic emergency department in Canada. Our study identified febrile (T>38.0°C) patients aged >18years presenting to our centre. Included participants must have had an ED based ECG at the time of presentation with fever and a comparison ECG performed within 30days and without fever. Actively paced patients were excluded. QT values were corrected using Bazett's, Fridericia's and The Framingham Formula. QT values for febrile and afebrile cohorts were compared using Related-Samples Wilcoxon Signed Rank Test. RESULTS: 181 patients satisfied our inclusion/exclusion criteria, 54.1% were female and mean age was 68.9years old. Mean duration between febrile and afebrile ECGs was 6.1days. The median corrected QT interval (QTc) was significantly shorter in patients during their febrile presentation, as compared to their afebrile presentation when correcting for QT using both Framingham [QTc=466.1ms (445.8-499.5) vs. 507.6 (476.0-539.0); p<0.001] and Fridericia's formula [QTc=388.7ms, (371.5-407.5) vs. 406.7ms, (386.1-434.4); p<0.001]. This difference was independent of gender. CONCLUSION: We found fever to shorten the QTc independently of sex in a general emergency department population.
Authors: Thanaporn Wattanakul; Bernhards Ogutu; Abdunoor M Kabanywanyi; Kwaku-Poku Asante; Abraham Oduro; Alex Adjei; Ali Sie; Esperanca Sevene; Eusebio Macete; Guillaume Compaore; Innocent Valea; Isaac Osei; Markus Winterberg; Margaret Gyapong; Martin Adjuik; Salim Abdulla; Seth Owusu-Agyei; Nicholas J White; Nicholas P J Day; Halidou Tinto; Rita Baiden; Fred Binka; Joel Tarning Journal: Antimicrob Agents Chemother Date: 2020-06-23 Impact factor: 5.191
Authors: Xin Hui S Chan; Yan Naung Win; Ilsa L Haeusler; Jireh Y Tan; Shanghavie Loganathan; Sompob Saralamba; Shu Kiat S Chan; Elizabeth A Ashley; Karen I Barnes; Rita Baiden; Peter U Bassi; Abdoulaye Djimde; Grant Dorsey; Stephan Duparc; Borimas Hanboonkunupakarn; Feiko O Ter Kuile; Marcus V G Lacerda; Amit Nasa; François H Nosten; Cyprian O Onyeji; Sasithon Pukrittayakamee; André M Siqueira; Joel Tarning; Walter R J Taylor; Giovanni Valentini; Michèle van Vugt; David Wesche; Nicholas P J Day; Christopher L-H Huang; Josep Brugada; Ric N Price; Nicholas J White Journal: PLoS Med Date: 2020-03-05 Impact factor: 11.069
Authors: Irena Andršová; Katerina Hnatkova; Martina Šišáková; Ondřej Toman; Peter Smetana; Katharina M Huster; Petra Barthel; Tomáš Novotný; Georg Schmidt; Marek Malik Journal: Sci Rep Date: 2021-07-12 Impact factor: 4.996