| Literature DB >> 28464501 |
Guanping Feng1, Marien Ochoa1,2, Jason R Maher1, Hani A Awad2,3, Andrew J Berger1,2.
Abstract
The development of spatially offset Raman spectroscopy (SORS) has enabled deep, non-invasive chemical characterization of turbid media. Here, we use SORS to measure subcortical bone tissue and depth-resolved biochemical variability in intact, exposed murine bones. We also apply the technique to study a mouse model of the genetic bone disorder osteogenesis imperfecta. The results suggest that SORS is more sensitive to disease-related biochemical differences in subcortical trabecular bone and marrow than conventional Raman measurements.Entities:
Keywords: bone; osteogenesis imperfecta; spatially offset Raman spectroscopy
Mesh:
Year: 2017 PMID: 28464501 PMCID: PMC5971662 DOI: 10.1002/jbio.201600317
Source DB: PubMed Journal: J Biophotonics ISSN: 1864-063X Impact factor: 3.207