Matteo Lambertini1, Oranite Goldrat, Florian Clatot, Isabelle Demeestere, Ahmad Awada. 1. aMedical Oncology Clinic bBreast Cancer Translational Research Laboratory, Institut Jules Bordet, l'Université Libre de Bruxelles (U.L.B.) cFertility Clinic, Research Laboratory on Human Reproduction Erasme, and l'Université Libre de Bruxelles (U.L.B.), Brussels, Belgium dMedical Oncology and IRON/U1245, Centre Henri Becquerel, Rouen, France.
Abstract
PURPOSE OF REVIEW: For trying to help physicians in counseling their young patients with breast cancer interested in fertility preservation and future reproductive plans, this manuscript aims to perform an overview of the main available data on 10 controversies in this field. RECENT FINDINGS: Thanks to the improvement in patients' prognosis, a growing attention towards fertility and pregnancy issues has been given over the past years and is currently provided to young breast cancer patients. However, several grey zones persist in many domains of this field and some physicians are still uncomfortable to deal with these issues. SUMMARY: Despite the great number of breast cancer patients experiencing fertility and pregnancy concerns at the time of diagnosis, the pursuit of fertility preserving strategies is realized only for a small proportion of them. The lack of adequate oncofertility counseling at the time of anticancer treatment decisions and the high costs of fertility preserving procedures can be considered the main explanations for these findings. The several ongoing registries and prospective studies investigating fertility and pregnancy issues in young breast cancer patients are crucial to acquire more robust data and try to address and solve the still unmet controversies in this field.
PURPOSE OF REVIEW: For trying to help physicians in counseling their young patients with breast cancer interested in fertility preservation and future reproductive plans, this manuscript aims to perform an overview of the main available data on 10 controversies in this field. RECENT FINDINGS: Thanks to the improvement in patients' prognosis, a growing attention towards fertility and pregnancy issues has been given over the past years and is currently provided to young breast cancerpatients. However, several grey zones persist in many domains of this field and some physicians are still uncomfortable to deal with these issues. SUMMARY: Despite the great number of breast cancerpatients experiencing fertility and pregnancy concerns at the time of diagnosis, the pursuit of fertility preserving strategies is realized only for a small proportion of them. The lack of adequate oncofertility counseling at the time of anticancer treatment decisions and the high costs of fertility preserving procedures can be considered the main explanations for these findings. The several ongoing registries and prospective studies investigating fertility and pregnancy issues in young breast cancerpatients are crucial to acquire more robust data and try to address and solve the still unmet controversies in this field.
Authors: Matteo Lambertini; Christine Campbell; José Bines; Larissa A Korde; Miguel Izquierdo; Debora Fumagalli; Lucia Del Mastro; Michail Ignatiadis; Kathleen Pritchard; Antonio C Wolff; Christian Jackisch; Istvan Lang; Michael Untch; Ian Smith; Frances Boyle; Binghe Xu; Carlos H Barrios; José Baselga; Alvaro Moreno-Aspitia; Martine Piccart; Richard D Gelber; Evandro de Azambuja Journal: J Natl Cancer Inst Date: 2019-01-01 Impact factor: 13.506
Authors: Nikita M Shah; Dana M Scott; Pridvi Kandagatla; Molly B Moravek; Erin F Cobain; Monika L Burness; Jacqueline S Jeruss Journal: Ann Surg Oncol Date: 2019-01-24 Impact factor: 5.344
Authors: Matteo Lambertini; Halle C F Moore; Robert C F Leonard; Sibylle Loibl; Pamela Munster; Marco Bruzzone; Luca Boni; Joseph M Unger; Richard A Anderson; Keyur Mehta; Susan Minton; Francesca Poggio; Kathy S Albain; Douglas J A Adamson; Bernd Gerber; Amy Cripps; Gianfilippo Bertelli; Sabine Seiler; Marcello Ceppi; Ann H Partridge; Lucia Del Mastro Journal: J Clin Oncol Date: 2018-05-02 Impact factor: 44.544