Identifying dynamic pathway interactions based on clinical information.

In this paper, we introduce approaches for inferring dynamic pathway interactions by converting static datasets into dynamic datasets using patients' clinical information. One approach uses survival time-based dynamic datasets, and the other uses grade- and stage-based dynamic datasets. Based on cancer grades and stages, we generated six dynamic levels and obtained two pairs of significant pathways out of twelve enriched pathways. One pair of the pathways included CELL ADHESION MOLECULES CAMS and SYSTEMIC LUPUS ERYTHEMATOSUS (correlation coefficient=1.00), in which CD28, CD86, HLA-DOA, and HLA-DOB were identified as common genes in the pathways. The other pair of the pathways included SPLICEOSOME and PRIMARY IMMUNODEFICIENCY (correlation coefficient=0.94) with no common genes identified.