Literature DB >> 2846328

Kynurenic acid antagonises responses to NMDA via an action at the strychnine-insensitive glycine receptor.

P J Birch1, C J Grossman, A G Hayes.   

Abstract

Kynurenate produces an unsurmountable antagonism of the response to N-methyl-D-aspartate (NMDA) in the baby rat hemisected spinal cord. This effect is completely reversible and prevented by co-superfusion with D-serine or glycine in the presence of strychnine. In the presence of D-serine kynurenate acts as a weak competitive antagonist. The results suggest that one of the actions of kynurenate is to antagonise NMDA responses via an action at the strychnine-insensitive glycine receptor.

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Year:  1988        PMID： 2846328     DOI： 10.1016/0014-2999(88)90367-6

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  77 in total

1.  Biochemical and structural characterization of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV.

Authors:  Qian Han; Howard Robinson; Tao Cai; Danilo A Tagle; Jianyong Li
Journal:  Biosci Rep       Date:  2011-10       Impact factor: 3.840

Review 2.  Glutamate receptor ion channels: structure, regulation, and function.

Authors:  Stephen F Traynelis; Lonnie P Wollmuth; Chris J McBain; Frank S Menniti; Katie M Vance; Kevin K Ogden; Kasper B Hansen; Hongjie Yuan; Scott J Myers; Ray Dingledine
Journal:  Pharmacol Rev       Date:  2010-09       Impact factor: 25.468

3.  Demonstration of kynurenine aminotransferases I and II and characterization of kynurenic acid synthesis in oligodendrocyte cell line (OLN-93).

Authors:  Katarzyna Wejksza; Wojciech Rzeski; Etsuo Okuno; Martyna Kandefer-Szerszen; Jan Albrecht; Waldemar A Turski
Journal:  Neurochem Res       Date:  2005-08       Impact factor: 3.996

Review 4.  A review of the in vitro and in vivo neurochemical characterization of the NMDA/PCP/glycine/ion channel receptor macrocomplex.

Authors:  P L Wood; T S Rao; S Iyengar; T Lanthorn; J Monahan; A Cordi; E Sun; M Vazquez; N Gray; P Contreras
Journal:  Neurochem Res       Date:  1990-02       Impact factor: 3.996

5.  Reply to: kynurenic acid and alcohol and cocaine dependence: novel effects and multiple mechanisms?

Authors:  Valentina Vengeliene
Journal:  Psychopharmacology (Berl)       Date:  2016-11-28       Impact factor: 4.530

Review 6.  Kynurenic Acid in Schizophrenia: A Systematic Review and Meta-analysis.

Authors:  Eric Plitman; Yusuke Iwata; Fernando Caravaggio; Shinichiro Nakajima; Jun Ku Chung; Philip Gerretsen; Julia Kim; Hiroyoshi Takeuchi; M Mallar Chakravarty; Gary Remington; Ariel Graff-Guerrero
Journal:  Schizophr Bull       Date:  2017-07-01       Impact factor: 9.306

Review 7.  Tryptophan, adenosine, neurodegeneration and neuroprotection.

Authors:  T W Stone; C M Forrest; G M Mackay; N Stoy; L G Darlington
Journal:  Metab Brain Dis       Date:  2007-12       Impact factor: 3.584

8.  Cycloleucine blocks NMDA responses in cultured hippocampal neurones under voltage clamp: antagonism at the strychnine-insensitive glycine receptor.

Authors:  N Hershkowitz; M A Rogawski
Journal:  Br J Pharmacol       Date:  1989-11       Impact factor: 8.739

9.  Neuroprotective kynurenine metabolite indices are abnormally reduced and positively associated with hippocampal and amygdalar volume in bipolar disorder.

Authors:  Jonathan Savitz; Robert Dantzer; Brent E Wurfel; Teresa A Victor; Bart N Ford; Jerzy Bodurka; P S F Bellgowan; T Kent Teague; Wayne C Drevets
Journal:  Psychoneuroendocrinology       Date:  2014-11-24       Impact factor: 4.905

10.  Thermal stability, pH dependence and inhibition of four murine kynurenine aminotransferases.

Authors:  Qian Han; Tao Cai; Danilo A Tagle; Jianyong Li
Journal:  BMC Biochem       Date:  2010-05-19       Impact factor: 4.059
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