Jiejing Qian1, Jie Jin1,2, Hong Luo3, Chunji Jin1, Lei Wang1, Wenbin Qian1, Haitao Meng1. 1. a Department of Hematology , The First Affiliated Hospital, Zhejiang University , Hangzhou , China. 2. b Institute of Hematology , Zhejiang University , Hangzhou , China. 3. c Department of Hematology , First hospital of Qiqihaer , Heilongjiang , China.
Abstract
OBJECTIVE: This study aims to explore the clinical features of multiple myeloma (MM) and the influence of various prognostic factors on survival. METHODS: A retrospective analysis, consisting of clinical characteristics analysis and laboratory examinations, was performed on 787 MM patients. Clinical and laboratory parameters were analyzed by multivariate process and compared across different groups. RESULTS: Of the 787 patients enrolled (median age, 61 years old, range 29-89 years old), 491 (62.4%) were male. Two most common complaints were bone pain (51.2%) and fatigue (48.0%). Anemia (hemoglobin (Hb) ≤100 g/L in female, Hb ≤110 g/L in male) was present initially in 69.4% patients. IgG was the most common type (46.6%). 52.2% of the patients were diagnosed on stage IIIA according to Durie-Salmon (D-S) system, 44.6% are on stage III according to International Staging System (ISS). Multivariate analysis suggested that age, serum calcium, LDH, percentage of abnormal plasma cells in bone marrow were all independent prognostic factors for OS. CONCLUSION: The MM patients in China are relatively younger, have higher rate on stage III according to D-S system. Older age, high serum calcium, high LDH, high percentage of abnormal plasma cells in bone marrow were highly related to poor prognosis.
OBJECTIVE: This study aims to explore the clinical features of multiple myeloma (MM) and the influence of various prognostic factors on survival. METHODS: A retrospective analysis, consisting of clinical characteristics analysis and laboratory examinations, was performed on 787 MMpatients. Clinical and laboratory parameters were analyzed by multivariate process and compared across different groups. RESULTS: Of the 787 patients enrolled (median age, 61 years old, range 29-89 years old), 491 (62.4%) were male. Two most common complaints were bone pain (51.2%) and fatigue (48.0%). Anemia (hemoglobin (Hb) ≤100 g/L in female, Hb ≤110 g/L in male) was present initially in 69.4% patients. IgG was the most common type (46.6%). 52.2% of the patients were diagnosed on stage IIIA according to Durie-Salmon (D-S) system, 44.6% are on stage III according to International Staging System (ISS). Multivariate analysis suggested that age, serum calcium, LDH, percentage of abnormal plasma cells in bone marrow were all independent prognostic factors for OS. CONCLUSION: The MMpatients in China are relatively younger, have higher rate on stage III according to D-S system. Older age, high serum calcium, high LDH, high percentage of abnormal plasma cells in bone marrow were highly related to poor prognosis.
Authors: Abdullah S Al Saleh; Harsh V Parmar; Alissa Visram; Eli Muchtar; Francis K Buadi; Ronald S Go; Angela Dispenzieri; Prashant Kapoor; Rahma Warsame; Martha Q Lacy; David Dingli; Nelson Leung; Wilson I Gonsalves; Taxiarchis V Kourelis; Morie A Gertz; Robert A Kyle; S Vincent Rajkumar; Shaji K Kumar Journal: Clin Lymphoma Myeloma Leuk Date: 2020-04-07