| Literature DB >> 28463008 |
Liao Peng1, Senyang Liu1, Anchao Feng2, Jinying Yuan1.
Abstract
Stimuli responsive polymers have been extensively studied as nanocarriers for drug delivery systems (DDSs), especially those based on supramolecular interactions. Cyclodextrin (CD) is one kind of widely applied host molecule, and the host-guest interactions between CD and different counterparts can respond to different stimuli and thus can be applied as responsive linkers for polymeric DDSs. In this review, the polymeric nanocarriers based on the host-guest interactions between CD and ferrocene, azobenzene, and benzimidazole as DDSs are summarized, with redox, light, and pH sensitivity, respectively. The mechanisms for the stimuli responsive ability of the linkers, the application of them for construction of DDSs with different polymer structures, and the controlled release behaviors have been focused. In addition, the outlook and challenge of these systems are discussed.Entities:
Keywords: drug delivery systems; host−guest chemistry; polymer self-assembly; stimuli responsive polymers; supramolecular structures
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Year: 2017 PMID： 28463008 DOI： 10.1021/acs.molpharmaceut.7b00160
Source DB: PubMed Journal: Mol Pharm ISSN： 1543-8384 Impact factor: 4.939