Elizaveta Chabanova1, Cilius Esmann Fonvig2, Christine Bøjsøe2, Jens-Christian Holm3, Henrik S Thomsen4. 1. Department of Diagnostic Radiology, Copenhagen University Hospital Herlev Gentofte, Herlev Ringvej 75, DK-2730 Herlev, Denmark. Electronic address: Elizaveta.Chabanova@regionh.dk. 2. The Children's Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Copenhagen, Denmark. 3. The Children's Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Copenhagen, Denmark; Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. 4. Department of Diagnostic Radiology, Copenhagen University Hospital Herlev Gentofte, Herlev Ringvej 75, DK-2730 Herlev, Denmark; Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Abstract
RATIONALE AND OBJECTIVES: The purpose of the present study was to obtain a cutoff value of liver fat content for the diagnosis of hepatic steatosis by comparing magnetic resonance (MR) spectroscopy results in children and adolescents with normal and excess weight. MATERIALS AND METHODS: The study included 420 children and adolescents (91 normal-weight, 99 overweight, and 230 obese) 8-18 years of age. Proton magnetic resonance spectroscopy was performed with a 3T MR system using point resolved spectroscopy sequence with series echo times. RESULTS: The mean absolute mass concentration of liver fat was obtained: 0.5 ± 0.04% in normal-weight boys; 0.5 ± 0.03% in normal-weight girls; 0.9 ± 0.16% in boys with overweight; 1.1 ± 0.24% in girls with overweight; 1.7 ± 0.24% in boys with obesity; and 1.4 ± 0.21% in girls with obesity. The cutoff value of absolute mass concentration of liver fat for hepatic steatosis was found to be 1.5%. Based on this cutoff value, hepatic steatosis was diagnosed in 16% of boys with overweight, 11% of girls with overweight, 32% of boys with obesity, and 27% of girls with obesity. CONCLUSIONS: Proton magnetic resonance spectroscopy was successfully applied to obtain the cutoff value of absolute mass concentration of liver fat for the diagnosis of hepatic steatosis in children and adolescents. Children and adolescents with obesity have higher risk of hepatic steatosis than their peers with overweight.
RATIONALE AND OBJECTIVES: The purpose of the present study was to obtain a cutoff value of liver fat content for the diagnosis of hepatic steatosis by comparing magnetic resonance (MR) spectroscopy results in children and adolescents with normal and excess weight. MATERIALS AND METHODS: The study included 420 children and adolescents (91 normal-weight, 99 overweight, and 230 obese) 8-18 years of age. Proton magnetic resonance spectroscopy was performed with a 3T MR system using point resolved spectroscopy sequence with series echo times. RESULTS: The mean absolute mass concentration of liver fat was obtained: 0.5 ± 0.04% in normal-weight boys; 0.5 ± 0.03% in normal-weight girls; 0.9 ± 0.16% in boys with overweight; 1.1 ± 0.24% in girls with overweight; 1.7 ± 0.24% in boys with obesity; and 1.4 ± 0.21% in girls with obesity. The cutoff value of absolute mass concentration of liver fat for hepatic steatosis was found to be 1.5%. Based on this cutoff value, hepatic steatosis was diagnosed in 16% of boys with overweight, 11% of girls with overweight, 32% of boys with obesity, and 27% of girls with obesity. CONCLUSIONS: Proton magnetic resonance spectroscopy was successfully applied to obtain the cutoff value of absolute mass concentration of liver fat for the diagnosis of hepatic steatosis in children and adolescents. Children and adolescents with obesity have higher risk of hepatic steatosis than their peers with overweight.
Authors: Mads J Skytte; Amirsalar Samkani; Amy D Petersen; Mads N Thomsen; Arne Astrup; Elizaveta Chabanova; Jan Frystyk; Jens J Holst; Henrik S Thomsen; Sten Madsbad; Thomas M Larsen; Steen B Haugaard; Thure Krarup Journal: Diabetologia Date: 2019-07-23 Impact factor: 10.122
Authors: Ahmad H Alzahrani; Mads J Skytte; Amirsalar Samkani; Mads N Thomsen; Arne Astrup; Christian Ritz; Elizaveta Chabanova; Jan Frystyk; Jens J Holst; Henrik S Thomsen; Sten Madsbad; Steen B Haugaard; Thure Krarup; Thomas Meinert Larsen; Faidon Magkos Journal: Eur J Nutr Date: 2021-06-08 Impact factor: 5.614
Authors: Sara E Stinson; Anna E Jonsson; Ierai Fernández de Retana Alzola; Morten A V Lund; Christine Frithioff-Bøjsøe; Louise Aas Holm; Cilius E Fonvig; Oluf Pedersen; Lars Ängquist; Thorkild I A Sørensen; Jens J Holst; Michael Christiansen; Jens-Christian Holm; Bolette Hartmann; Torben Hansen Journal: J Clin Endocrinol Metab Date: 2022-05-17 Impact factor: 6.134
Authors: Mads N Thomsen; Mads J Skytte; Amirsalar Samkani; Martin H Carl; Philip Weber; Arne Astrup; Elizaveta Chabanova; Mogens Fenger; Jan Frystyk; Bolette Hartmann; Jens J Holst; Thomas M Larsen; Sten Madsbad; Faidon Magkos; Henrik S Thomsen; Steen B Haugaard; Thure Krarup Journal: Diabetologia Date: 2022-01-07 Impact factor: 10.122