Becky I Haynes1, Sarah Bauermeister2, David Bunce1. 1. 1School of Psychology,University of Leeds,Leeds,United Kingdom. 2. 2Department of Psychiatry,University of Oxford,Oxford,United Kingdom.
Abstract
OBJECTIVES: Intraindividual variability (IIV) in reaction time refers to the trial-to-trial fluctuations in responding across a given cognitive task. Cross-sectional research suggests that IIV increases with normal and neuropathological ageing and it may serve as a marker of neurobiological integrity. This raises the possibility that IIV may also predict future cognitive decline and, indeed, neuropathology. Therefore, we conducted a systematic review to address these issues. METHODS: A search of electronic databases Embase, Medline, PsycINFO, and Web of Science was completed on May 17, 2016 that identified longitudinal investigations of IIV in middle-aged or older adults. RESULTS: A total of 688 studies were initially identified of which 22 met the inclusion criteria. Nine included longitudinal IIV measures and 17 predicted subsequent outcome (cognitive decline or impairment, dementia, mortality) from baseline IIV. The results suggested IIV increased over time, particularly in participants aged over 75 years. Greater baseline IIV was consistently associated with increased risk of adverse outcomes including cognitive decline or impairment, and mortality. CONCLUSIONS: Increased IIV over time is associated with normal ageing. However, further increases in IIV over and above those found in normal ageing may be a risk factor for future cognitive impairment or mortality. Measures of IIV may, therefore, have considerable potential as a supplement to existing clinical assessment to aid identification of individuals at risk of adverse outcomes such as dementia or death. (JINS, 2017, 23, 431-445).
OBJECTIVES: Intraindividual variability (IIV) in reaction time refers to the trial-to-trial fluctuations in responding across a given cognitive task. Cross-sectional research suggests that IIV increases with normal and neuropathological ageing and it may serve as a marker of neurobiological integrity. This raises the possibility that IIV may also predict future cognitive decline and, indeed, neuropathology. Therefore, we conducted a systematic review to address these issues. METHODS: A search of electronic databases Embase, Medline, PsycINFO, and Web of Science was completed on May 17, 2016 that identified longitudinal investigations of IIV in middle-aged or older adults. RESULTS: A total of 688 studies were initially identified of which 22 met the inclusion criteria. Nine included longitudinal IIV measures and 17 predicted subsequent outcome (cognitive decline or impairment, dementia, mortality) from baseline IIV. The results suggested IIV increased over time, particularly in participants aged over 75 years. Greater baseline IIV was consistently associated with increased risk of adverse outcomes including cognitive decline or impairment, and mortality. CONCLUSIONS: Increased IIV over time is associated with normal ageing. However, further increases in IIV over and above those found in normal ageing may be a risk factor for future cognitive impairment or mortality. Measures of IIV may, therefore, have considerable potential as a supplement to existing clinical assessment to aid identification of individuals at risk of adverse outcomes such as dementia or death. (JINS, 2017, 23, 431-445).
Authors: Christopher R Brydges; Michelle C Carlson; Ryan M Andrews; George W Rebok; Allison A M Bielak Journal: J Gerontol B Psychol Sci Soc Sci Date: 2021-03-14 Impact factor: 4.077
Authors: Carlos Hernaiz Alonso; Jared J Tanner; Margaret E Wiggins; Preeti Sinha; Hari K Parvataneni; Mingzhou Ding; Christoph N Seubert; Mark J Rice; Cynthia W Garvan; Catherine C Price Journal: PLoS One Date: 2019-05-23 Impact factor: 3.240
Authors: Nasreen Basoudan; Anna Torrens-Burton; Amy Jenkins; Ian M Thornton; Claire Hanley; Jeremy J Tree; Sara Thomas; Andrea Tales Journal: Yale J Biol Med Date: 2019-03-25
Authors: João Bento-Torres; Natáli Valim Oliver Bento-Torres; Chelsea M Stillman; George A Grove; Haiqing Huang; Fatma Uyar; Jennifer C Watt; Mariegold E Wollam; Kirk I Erickson Journal: J Sport Health Sci Date: 2019-03-20 Impact factor: 7.179
Authors: Eelco van Duinkerken; Guilherme J Schmidt; Ana Lúcia Taboada Gjorup; Carolina Ribeiro Mello; André Casarsa Marques; Áureo do Carmo Filho; Paula Regina Yuri Fukusawa; Simone Gonçalves de Assis; Júlio Cesar Tolentino; Sergio L Schmidt Journal: Behav Neurol Date: 2021-06-25 Impact factor: 3.342