| Literature DB >> 28461108 |
Maria Giulia Santaguida1, Ilenia Gatto1, Giorgio Mangino1, Camilla Virili1, Ilaria Stramazzo1, Poupak Fallahi2, Alessandro Antonelli2, Maria Segni3, Giovanna Romeo1, Marco Centanni4.
Abstract
Hashimoto thyroiditis (HT) may occur isolated or associated with other non-endocrine autoimmune disorders (NEAD). No data are available about Breg cells in these disorders and this represented the aim of the study. Th17 and Breg cells subset were characterized on peripheral blood mononuclear cells isolated from 18 healthy donors (HD), 19 patients with isolated HT and 26 patients with HT+NEAD. Th17 were higher in patients with isolated HT than in HD but no further changes were seen in patients with HT+NEAD. CD24hiCD38hi unstimulated Breg cells were similar in HT patients and in HD, but significantly higher in patients with HT+NEAD than in both HT and in HD. CD19+CD24hiCD27+ Breg memory phenotype was similar in HD and in HT patients, but decreased in patients with HT+NEAD (23.4%vs38.5%). Upon CpG-stimulation, CD24hiCD38hi IL-10+ Breg cells were higher in HT patients than in HD (3.9%vs1.8%) but similar in patients with HT+NEAD (2.4%).Entities:
Keywords: Breg cells; Cellular immunity; Hashimoto's thyroiditis; Polyglandular autoimmune syndrome; Thyroid autoimmunity
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Year: 2017 PMID： 28461108 DOI： 10.1016/j.clim.2017.04.012
Source DB: PubMed Journal: Clin Immunol ISSN： 1521-6616 Impact factor: 3.969