| Literature DB >> 28461063 |
Liang Tang1, Jing Zhang1, Xinjuan Zhao1, Nan Li1, Wenqi Jian1, Shuxin Sun2, Jianzhong Guo3, Lijun Sun4, Dean Ta5.
Abstract
The purpose of this study was to investigate whether low-intensity pulsed ultrasound (LIPUS) promotes exercise-induced muscle hypertrophy. Twenty-four adult Sprague-Dawley (SD) rats were randomly assigned to three groups (n = 8 per group): normal control group (NC), treadmill exercise group (TE) and treadmill exercise + LIPUS group (TE + LIPUS). The TE + LIPUS group received a LIPUS treatment (1 MHz, 30 mW/cm2) at the gastrocnemius for 20 min/d after treadmill exercise. The TE group was sham-treated. Eight weeks of treadmill training successfully established the exercise-induced muscle hypertrophy model. Muscle strength, muscle mass and muscle fiber cross-sectional area were significantly increased in the TE + LIPUS group compared with the TE group. Moreover, LIPUS treatment significantly upregulated the expression of Akt, mTOR, p-Akt and p-mTOR and significantly downregulated the expression of MSTN, ActRIIB, FoxO1 and its phosphorylation. The results indicated that LIPUS promotes exercise-induced muscle hypertrophy by facilitating protein synthesis and inhibiting the protein catabolism pathway.Entities:
Keywords: Low-intensity pulsed ultrasound; Protein catabolism; Protein synthesis; Skeletal muscle hypertrophy; Treadmill exercise
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Year: 2017 PMID： 28461063 DOI： 10.1016/j.ultrasmedbio.2017.02.017
Source DB: PubMed Journal: Ultrasound Med Biol ISSN： 0301-5629 Impact factor: 2.998