Sung Keun Park1, Kanghee Moon2, Jae-Hong Ryoo2, Chang-Mo Oh2, Joong-Myung Choi2, Jeong Gyu Kang3, Ju Youn Chung4, Ju Young Jung2,3. 1. Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 04514 Seoul, Republic of Korea. 2. Department of Preventive Medicine, School of Medicine, Kyung Hee University, 02453 Seoul, Korea. 3. Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of medicine, 78 Saemunan-gil, Jongro-Gu, Seoul 110-746, Korea. 4. Department of Industrial Design, Chonbuk National University, College of Arts, 28644 Jeollabuk-do, Korea.
Abstract
Aims: The adverse effect of heavy alcohol intake on cardiovascular disease is well established. However, there is only limited information about the risk of subclinical left ventricular (LV) abnormality according to alcohol consumption. Thus, this study was to investigate the association between alcohol consumption and LV functional and structural abnormality. Methods and results: Study participants were 49 714 Korean adults received echocardiogram as an item of health check-up program. They were stratified into 6 groups according to alcohol consumption; non (life time never drinker), occasional (<1 g/day), light (1-15 g/day), moderate (15-30 g/day), heavy (30-60 g/day), and very heavy (>60 g/day) drinker. Multiple logistic regression analysis was used to assess the odd ratios (ORs) for LV hypertrophy (LVH), increased relative wall thickness (RWT) and impaired LV diastolic (LVD) function with a reference of non-drinker. Additionally, the adjusted mean values of echocardiographic parameters were evaluated to assess LV diastolic function and structure. In logistic regression analysis, very heavy alcohol drinker had the highest adjusted ORs for LVH, increased RWT and impaired LVD function in all participants and male subgroup (P < 0.05). The dose dependent relationship was found between alcohol consumption and impaired LVD function in all participants and gender subgroups. There was no specific pattern of relationship to suggest the favourable effect of light alcohol drinking on heart. Conclusion: Increased alcohol intake had the adverse effect on LV function and structure. However, potential favourable effect of light alcohol intake was not observed. Prospective studies are required to investigate long-term effect of alcohol consumption on subclinical LV change. Published on behalf of the European Society of Cardiology. All rights reserved.
Aims: The adverse effect of heavy alcohol intake on cardiovascular disease is well established. However, there is only limited information about the risk of subclinical left ventricular (LV) abnormality according to alcohol consumption. Thus, this study was to investigate the association between alcohol consumption and LV functional and structural abnormality. Methods and results: Study participants were 49 714 Korean adults received echocardiogram as an item of health check-up program. They were stratified into 6 groups according to alcohol consumption; non (life time never drinker), occasional (<1 g/day), light (1-15 g/day), moderate (15-30 g/day), heavy (30-60 g/day), and very heavy (>60 g/day) drinker. Multiple logistic regression analysis was used to assess the odd ratios (ORs) for LV hypertrophy (LVH), increased relative wall thickness (RWT) and impaired LV diastolic (LVD) function with a reference of non-drinker. Additionally, the adjusted mean values of echocardiographic parameters were evaluated to assess LV diastolic function and structure. In logistic regression analysis, very heavy alcohol drinker had the highest adjusted ORs for LVH, increased RWT and impaired LVD function in all participants and male subgroup (P < 0.05). The dose dependent relationship was found between alcohol consumption and impaired LVD function in all participants and gender subgroups. There was no specific pattern of relationship to suggest the favourable effect of light alcohol drinking on heart. Conclusion: Increased alcohol intake had the adverse effect on LV function and structure. However, potential favourable effect of light alcohol intake was not observed. Prospective studies are required to investigate long-term effect of alcohol consumption on subclinical LV change. Published on behalf of the European Society of Cardiology. All rights reserved.
Authors: Olena Iakunchykova; Henrik Schirmer; Darryl Leong; Sofia Malyutina; Andrew Ryabikov; Maria Averina; Alexander Kudryavtsev; Mikhail Kornev; Ekaterina Voronina; Andrey Paramonov; Tom Wilsgaard; David Leon Journal: Open Heart Date: 2021-06
Authors: Andrea Kolkenbeck-Ruh; Larske M Soepnel; Simone H Crouch; Sanushka Naidoo; Wayne Smith; Shane A Norris; Justine Davies; Lisa J Ware Journal: BMC Cardiovasc Disord Date: 2022-09-09 Impact factor: 2.174