Literature DB >> 2845978

Structure of the human blood platelet membrane glycoprotein Ib alpha gene.

R H Wenger1, N Kieffer, A N Wicki, K J Clemetson.   

Abstract

The gene for human platelet glycoprotein Ib alpha-chain has been cloned from a genomic cosmid library using a partial cDNA clone as probe. 3530 bp were sequenced including the entire transcribed part, as well as additional 5' and 3' regions. A single intron was found 6 bp upstream of the ATG initiation codon. An exceptionally long exon was identical to the recently published cDNA sequence (1). The 5' upstream promoter region is atypical for eukaryotic genes with only a weak homology to the characteristic promoter consensus sequences. The 3' region contains two repetitive Alu elements, belonging to distinct subfamilies, connected by an oligo(dA) linker.

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Year:  1988        PMID： 2845978     DOI： 10.1016/s0006-291x(88)80853-2

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  13 in total

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Authors:  J L Miller; D Cunningham; V A Lyle; C N Finch
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-01       Impact factor: 11.205

5.  Structure of the human sialophorin (CD43) gene. Identification of features atypical of genes encoding integral membrane proteins.

Authors:  C S Shelley; E Remold-O'Donnell; F S Rosen; A S Whitehead
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Authors:  B Schumpp-Vonach; G Kresbach; E J Schlaeger; B Steiner
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7.  Point mutation in a leucine-rich repeat of platelet glycoprotein Ib alpha resulting in the Bernard-Soulier syndrome.

Authors:  J Ware; S R Russell; P Marchese; M Murata; M Mazzucato; L De Marco; Z M Ruggeri
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8.  Cloning of porcine platelet glycoprotein Ibα and comparison with the human homolog.

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Authors:  R W Kuijpers; N M Faber; H T Cuypers; W H Ouwehand; A E von dem Borne
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10.  Nonsense mutation in the glycoprotein Ib alpha coding sequence associated with Bernard-Soulier syndrome.

Authors:  J Ware; S R Russell; V Vicente; R E Scharf; A Tomer; R McMillan; Z M Ruggeri
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