Literature DB >> 28458613

Causal analysis of ordinal treatments and binary outcomes under truncation by death.

Linbo Wang1, Thomas S Richardson1, Xiao-Hua Zhou1,2.   

Abstract

It is common that in multi-arm randomized trials, the outcome of interest is "truncated by death," meaning that it is only observed or well-defined conditioning on an intermediate outcome. In this case, in addition to pairwise contrasts, the joint inference for all treatment arms is also of interest. Under a monotonicity assumption we present methods for both pairwise and joint causal analyses of ordinal treatments and binary outcomes in presence of truncation by death. We illustrate via examples the appropriateness of our assumptions in different scientific contexts.

Entities:  

Keywords:  Bayesian analysis; Causal inference; Multi-arm trials; Ordinal treatment variable; Principal stratification; Survey incentives

Year:  2016        PMID: 28458613      PMCID: PMC5407214          DOI: 10.1111/rssb.12188

Source DB:  PubMed          Journal:  J R Stat Soc Series B Stat Methodol        ISSN: 1369-7412            Impact factor:   4.488


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