| Literature DB >> 28458561 |
Dawei Rong1, Weiwei Tang1, Zhouxiao Li1,2, Jian Zhou3, Junfeng Shi4, Hanjin Wang1, Hongyong Cao1.
Abstract
Circular RNAs (circRNAs), formed by nonsequential back-splicing of pre-messenger RNA (pre-mRNA) transcripts, have been widely concerned in recent years. With advances in high-throughput RNA sequencing (RNA-seq) technology, previous work has revealed that a large number of circRNAs, which are endogenous, abundant and stable in mammalian cells, may be involved in atherosclerotic vascular disease risk, neurological disorders, prion diseases and carcinomas. Remarkably, interaction between circRNAs and microRNA has already been observed to perform a significant role in a variety of cancers, including gastric cancer and colorectal cancer. Recent work has suggested that circRNAs may play critical roles in the initiation and development of cancers and could become potential new biomarkers for cancers. Herein, we review the current understanding of the roles of circRNAs in cancers and the potential implications of circRNAs in cancer-targeted therapy.Entities:
Keywords: circular; diagnosis; microRNA; noncoding RNA; targeted therapy
Year: 2017 PMID: 28458561 PMCID: PMC5403007 DOI: 10.2147/OTT.S134403
Source DB: PubMed Journal: Onco Targets Ther ISSN: 1178-6930 Impact factor: 4.147
Figure 1Mechanism of circRNAs functioning as competing endogenous RNAs or miRNA sponges.
Abbreviations: circRNAs, circular RNAs; miRNA, microRNA; mRNA, messenger RNA.
Literature of circRNAs and carcinomas
| Type of cancer | First author | Received date | Journal | Sequence name or more content | Expression |
|---|---|---|---|---|---|
| Cutaneous squamous cell carcinoma | Sand M | 2016/6/15 | Picking out 322 circRNAs | cir-143↑, cir-179↓ | |
| BCC | Sand M | 2016/4/21 | Screening out 71 circRNAs | 23 circRNAs↑, 48 circRNAs↓ | |
| Epithelial ovarian carcinoma | Ahmed I | 2016/4/28 | Altered expression pattern | Unclear | |
| Ovarian carcinoma | Bachmayr-Heyda A | 2016/5/14 | Unclear | Unclear | |
| Cervical cancer | Abdelmohsen K | 2017/1/13 | CircPABPN1 (hsa_circ_0031288) | Unclear | |
| Laryngeal cancer | Xuan L | 2016/5/10 | hsa_circ_104912, hsa_circ_100855 | hsa_circ_104912↓, hsa_circ_100855↑ | |
| Hepatoma carcinoma | Qin M | 2015/11/26 | hsa_circ_0001649 | hsa_circ_0001649↓ | |
| Hepatoma carcinoma | Yu L | 2016/7/9 | circRNA Cdr1 | circRNA Cdr1↑ | |
| Hepatoma carcinoma | Shang X | 2016/6/4 | hsa_circ_0000520, hsa_circ_0005075, hsa_circ_0066444 | Unclear | |
| Hepatoma carcinoma | Xu L | 2016/9/12 | ciRS-7 (Cdr1as) | ciRS-7 (Cdr1as)↓ | |
| Pancreatic ductal carcinoma | Qu S | 2015/10/21 | Microarray expression profile | Unclear | |
| Neuroglioma | Song X | 2016/2/14 | Screening out 476 circRNAs | Unclear | |
| Neuroglioma | Barbagallo D | 2015/12/20 | Unclear | Unclear | |
| Neuroglioma | Yang P | 2016/9/11 | cZNF292 circRNA | cZNF292 circRNA↓ | |
| Colorectal cancer | Wang X | 2016/2/18 | hsa_circ_001988 | hsa_circ_001988↓ | |
| Colorectal cancer, ovarian carcinoma | Bachmayr-Heyda A | 2015/1/28 | The percent of circ/line | The percent of circ/line↓ | |
| Colorectal cancer | Xie H | 2016/4/9 | hsa_circ_001569 | hsa_circ_001569↑ | |
| Colorectal cancer | Huang G | 2015/6/26 | cir-ITCH | cir-ITCH↓ | |
| Colorectal cancer | Zhu M | 2017/1/20 | circ-BANP | circ-BANP↑ | |
| KRAS mutant colon cancer | Dou Y | 2016/11/29 | circRNA | circRNA↓ | |
| Gastric carcinoma | Li P | 2015/2/18 | hsa_circ_002059 | hsa_circ_002059↓ | |
| Gastric carcinoma | Li P | 2017/1/13 | hsa_circ_0000096 | hsa_circ_0000096↓ | |
| Gastric carcinoma | Chen S | 2017/1/29 | hsa_circ_0000190 | hsa_circ_0000190↓ | |
| Esophageal carcinoma | Xia W | 2016/10/19 | hsa_circ_0067934 | hsa_circ_0067934↑ | |
| Radio-resistant esophageal cancer | Su H | 2016/7/29 | hsa_circ_001059, hsa_circ_100385, hsa_circ_104983, hsa_circ_000167, hsa_circ_101877, hsa_circ_102913, hsa_circ_000695 | hsa_circ_001059↑, hsa_circ_100385↑, hsa_circ_104983↑, hsa_circ_000167↓, hsa_circ_101877↓, hsa_circ_102913↓, hsa_circ_000695↓ | |
| Esophageal carcinoma | Li F | 2015/3/10 | cir-ITCH | cir-ITCH↓ | |
| Hematopoiesis malignancies | Bonizzato A | 2016/10/16 | Screening out the expression of circRNAs | Unclear | |
| Bladder carcinoma | Zhong Z | 2016/8/4 | circTCF25 | circTCF25↑ | |
| Bladder carcinoma | Huang M | 2016/7/1 | circRNA M, YLK | Unclear | |
| Clear cell renal cell carcinoma | Wang K | 2017/1/17 | circHIAT1 | circHIAT1↓ | |
| Breast cancer | Yang W | 2015/12/15 | Foxo3 circRNA | Foxo3 circRNA↑ | |
| Breast cancer | Nair AA | 2016/11/10 | Unclear | Unclear | |
| Lung cancer | Wan L | 2016/9/20 | circRNA-ITCH | circRNA-ITCH↓ | |
| Seven cancers | Zheng Q | 2016/4/7 | circHIPK3 | circHIPK3↓ | |
| Cancer | Du WW | 2016/2/11 | circ-Foxo3 | circ-Foxo3↓ | |
| Cancer | Hansen TB | 2011/10/4 | CDR1 | Unclear | |
| Carcinoma | Du WW | 2016/11/26 | circ-Foxo3 | circ-Foxo3↓ |
Notes: ↓ means downregulated. ↑ means upregulated.
Abbreviations: circRNAs, circular RNA; BCC, basal cell carcinoma.