Chrisanthi Marakaki1, Olga Karapanou1, Alexandros Gryparis2, Ze'ev Hochberg3, George Chrousos4, Anastasios Papadimitriou5. 1. Third Department of Pediatrics, National and Kapodistrian University of Athens School of Medicine, "Attikon" University Hospital, Athens, Greece. 2. Department of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens School of Medicine, Athens, Greece. 3. Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. 4. First Department of Pediatrics, Division of Endocrinology, Metabolism and Diabetes, National and Kapodistrian University of Athens School of Medicine, Aghia Sophia Children's Hospital, Athens, Greece. 5. Third Department of Pediatrics, National and Kapodistrian University of Athens School of Medicine, "Attikon" University Hospital, Athens, Greece. Electronic address: anpapad@med.uoa.gr.
Abstract
OBJECTIVES: To examine differences in the growth pattern and the age at adiposity rebound (AR) between children with premature adrenarche (PA) and their healthy peers (controls). STUDY DESIGN: In this cross-sectional study of 82 prepubertal children with PA and 63 controls, the main outcome measures were height and body mass index SDS progression, from birth to presentation at the clinic, baseline biochemical and hormonal evaluation, bone age determination, and age at AR. RESULTS: Children with PA were significantly taller and more adipose than controls from the first years of life. 33% of children with PA presented the growth pattern of constitutional advancement of growth (ie, early growth acceleration) vs 19% of controls (P = .045). Children with PA had an earlier AR compared with controls; mean age at AR in girls with PA was 3.73 (1.03) years vs 4.93 (1.36) years for control girls (P = .001) and in boys with PA was 3.45 (0.73) vs 5.10 (1.50) years in control boys (P = .048). Both obese and nonobese girls with PA were taller and had earlier age at AR compared with nonobese controls. CONCLUSIONS: Early AR and constitutional advancement of growth may be triggering factors for adrenal androgen production and PA.
OBJECTIVES: To examine differences in the growth pattern and the age at adiposity rebound (AR) between children with premature adrenarche (PA) and their healthy peers (controls). STUDY DESIGN: In this cross-sectional study of 82 prepubertal children with PA and 63 controls, the main outcome measures were height and body mass index SDS progression, from birth to presentation at the clinic, baseline biochemical and hormonal evaluation, bone age determination, and age at AR. RESULTS:Children with PA were significantly taller and more adipose than controls from the first years of life. 33% of children with PA presented the growth pattern of constitutional advancement of growth (ie, early growth acceleration) vs 19% of controls (P = .045). Children with PA had an earlier AR compared with controls; mean age at AR in girls with PA was 3.73 (1.03) years vs 4.93 (1.36) years for control girls (P = .001) and in boys with PA was 3.45 (0.73) vs 5.10 (1.50) years in control boys (P = .048). Both obese and nonobesegirls with PA were taller and had earlier age at AR compared with nonobese controls. CONCLUSIONS: Early AR and constitutional advancement of growth may be triggering factors for adrenal androgen production and PA.
Authors: Izzuddin M Aris; Sheryl L Rifas-Shiman; Ling-Jun Li; Ken P Kleinman; Brent A Coull; Diane R Gold; Marie-France Hivert; Michael S Kramer; Emily Oken Journal: Int J Epidemiol Date: 2019-02-01 Impact factor: 7.196
Authors: Jani Liimatta; Pauliina Utriainen; Raimo Voutilainen; Jarmo Jääskeläinen Journal: Front Endocrinol (Lausanne) Date: 2018-07-10 Impact factor: 5.555