| Literature DB >> 28455710 |
Martin Lee1, Kevin Rey1, Katrina Besler1, Christine Wang1, Jonathan Choy2.
Abstract
Nitric oxide (NO) is a bioactive gas that has multiple roles in innate and adaptive immune responses. In macrophages, nitric oxide is produced by inducible nitric oxide synthase upon microbial and cytokine stimulation. It is needed for host defense against pathogens and for immune regulation. This review will summarize the role of NO and iNOS in inflammatory and immune responses and will discuss the regulatory mechanisms that control inducible nitric oxide synthase expression and activity.Entities:
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Year: 2017 PMID: 28455710 DOI: 10.1007/978-3-319-54090-0_8
Source DB: PubMed Journal: Results Probl Cell Differ ISSN: 0080-1844