Literature DB >> 28455628

Identification of antigenic proteins in Strongyloides stercoralis by proteomic analysis.

Rutchanee Rodpai1,2, Pewpan M Intapan1,2, Tongjit Thanchomnang2,3, Oranuch Sanpool1,2,3, Penchom Janwan2,4, Porntip Laummaunwai1, Chaisiri Wongkham5, Tonkla Insawang6, Wanchai Maleewong7,8.   

Abstract

Strongyloides stercoralis is an intestinal helminth that infects people worldwide. Hyperinfection or disseminated human strongyloidiasis can involve vital organs, leading to lethal outcomes. We analyzed immunoproteomics of antigenic spots, derived from S. stercoralis third-stage larvae and reacted with human strongyloidiasis sera, by two-dimensional gel electrophoresis and immunoblotting. Of 26 excised antigenic spots analyzed by liquid chromatography-electrospray ionization-tandem mass spectrometry, 20 proteins were identified. Most proteins were associated with enzymes involved in the metabolic process, energy generation, and oxidation-reduction. The proteins relate to promotion of worm development, cell division, cell signaling and transportation, and regulation of muscular contraction. Identification of antigenic proteins shows promise in helping to discover potential diagnostic protein markers or vaccine candidates for S. stercoralis infection.

Entities:  

Keywords:  Antigenic proteins; Intestinal helminth; Mass spectrometry; Proteomic analysis; Strongyloides stercoralis

Mesh：

Substances：

Year:  2017        PMID： 28455628     DOI： 10.1007/s00436-017-5443-9

Source DB:  PubMed          Journal:  Parasitol Res        ISSN： 0932-0113            Impact factor:   2.289


  22 in total

1.  Is tropomyosin an allergen in Anisakis?

Authors:  J A Asturias; E Eraso; I Moneo; A Martínez
Journal:  Allergy       Date:  2000-09       Impact factor: 13.146

Review 2.  The 14-3-3 protein: a key molecule in parasites as in other organisms.

Authors:  María del Mar Siles-Lucas; Bruno Gottstein
Journal:  Trends Parasitol       Date:  2003-12

Review 3.  Calponins: adaptable modular regulators of the actin cytoskeleton.

Authors:  Guido T Rozenblum; Mario Gimona
Journal:  Int J Biochem Cell Biol       Date:  2007-07-31       Impact factor: 5.085

4.  [Cloning, expression and immunodiagnostic evaluation of enolase from Echinococcus granulosus].

Authors:  Ying Wang; Jing Zhang; Zhong-Ying Yuan; He-Jun Zhou; Yu-Juan Shen; Yu-Xin Xu; Yan-Juan Wang; Wei-Ping Wu; Jian-Ping Cao
Journal:  Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi       Date:  2012-10

5.  Purification and characterization of the 2-methyl branched-chain Acyl-CoA dehydrogenase, an enzyme involved in NADH-dependent enoyl-CoA reduction in anaerobic mitochondria of the nematode, Ascaris suum.

Authors:  R Komuniecki; S Fekete; J Thissen-Parra
Journal:  J Biol Chem       Date:  1985-04-25       Impact factor: 5.157

Review 6.  Strongyloides stercoralis: Global Distribution and Risk Factors.

Authors:  Fabian Schär; Ulf Trostdorf; Federica Giardina; Virak Khieu; Sinuon Muth; Hanspeter Marti; Penelope Vounatsou; Peter Odermatt
Journal:  PLoS Negl Trop Dis       Date:  2013-07-11

7.  The transcriptome analysis of Strongyloides stercoralis L3i larvae reveals targets for intervention in a neglected disease.

Authors:  Antonio Marcilla; Gagan Garg; Dolores Bernal; Shoba Ranganathan; Javier Forment; Javier Ortiz; Carla Muñoz-Antolí; M Victoria Dominguez; Laia Pedrola; Juan Martinez-Blanch; Javier Sotillo; Maria Trelis; Rafael Toledo; J Guillermo Esteban
Journal:  PLoS Negl Trop Dis       Date:  2012-02-28

8.  cGMP and NHR signaling co-regulate expression of insulin-like peptides and developmental activation of infective larvae in Strongyloides stercoralis.

Authors:  Jonathan D Stoltzfus; Stephen M Bart; James B Lok
Journal:  PLoS Pathog       Date:  2014-07-10       Impact factor: 6.823

Review 9.  Strongyloidiasis: A Disease of Socioeconomic Disadvantage.

Authors:  Meruyert Beknazarova; Harriet Whiley; Kirstin Ross
Journal:  Int J Environ Res Public Health       Date:  2016-05-20       Impact factor: 3.390

10.  The genomic basis of parasitism in the Strongyloides clade of nematodes.

Authors:  Vicky L Hunt; Isheng J Tsai; Avril Coghlan; Adam J Reid; Nancy Holroyd; Bernardo J Foth; Alan Tracey; James A Cotton; Eleanor J Stanley; Helen Beasley; Hayley M Bennett; Karen Brooks; Bhavana Harsha; Rei Kajitani; Arpita Kulkarni; Dorothee Harbecke; Eiji Nagayasu; Sarah Nichol; Yoshitoshi Ogura; Michael A Quail; Nadine Randle; Dong Xia; Norbert W Brattig; Hanns Soblik; Diogo M Ribeiro; Alejandro Sanchez-Flores; Tetsuya Hayashi; Takehiko Itoh; Dee R Denver; Warwick Grant; Jonathan D Stoltzfus; James B Lok; Haruhiko Murayama; Jonathan Wastling; Adrian Streit; Taisei Kikuchi; Mark Viney; Matthew Berriman
Journal:  Nat Genet       Date:  2016-02-01       Impact factor: 38.330
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  4 in total

1.  Proteomic analysis of the excretory-secretory products from Strongyloides venezuelensis infective larvae: new insights for the immunodiagnosis of human strongyloidiasis.

Authors:  William Henry Roldán Gonzáles; Guilherme Rabelo Coelho; Daniel Carvalho Pimenta; Fabiana Martins de Paula; Ronaldo Cesar Borges Gryschek
Journal:  Parasitol Res       Date:  2022-08-31       Impact factor: 2.383

2.  Identification and Immunological Characterization of Somatic Proteins from Adults of Toxocara cati by Proteomics Technique.

Authors:  Nooshinmehr Soleymani; Ruth Birner Grunberger; Khalil Abnous; Hassan Borji; Faezeh Vahdati
Journal:  Iran J Parasitol       Date:  2021 Jan-Mar       Impact factor: 1.012

3.  Evaluation of the Immunomodulatory Effect of the Recombinant 14-3-3 and Major Antigen Proteins of Strongyloides stercoralis against an Infection by S. venezuelensis.

Authors:  Liz F Sánchez-Palencia; María Trelis; Julio López-Abán; Alicia Galiano; Belén Vicente; Esther Del Olmo; Antonio Muro; Dolores Bernal; Antonio Marcilla
Journal:  Vaccines (Basel)       Date:  2022-08-10

Review 4.  Prospects of Using High-Throughput Proteomics to Underpin the Discovery of Animal Host-Nematode Interactions.

Authors:  Tao Wang; Robin B Gasser
Journal:  Pathogens       Date:  2021-06-30
  4 in total

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