Michael P Diamond1, Richard S Legro2, Christos Coutifaris3, Ruben Alvero4, Randal D Robinson5, Peter A Casson6, Gregory M Christman7, Hao Huang8, Karl R Hansen9, Valerie Baker10, Rebecca Usadi11, Aimee Seungdamrong12, G Wright Bates13, R Mitchell Rosen14, William Schlaff4, Daniel Haisenleder15, Stephen A Krawetz16, Kurt Barnhart3, J C Trussell17, Nanette Santoro4, Esther Eisenberg18, Heping Zhang8. 1. Department of Obstetrics and Gynecology, Georgia Regents University, Augusta, GA; Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI. Electronic address: michael.diamond@augusta.edu. 2. Department of Obstetrics and Gynecology, Pennsylvania State University, Hershey, PA. 3. Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA. 4. Department of Obstetrics and Gynecology, University of Colorado, Denver, CO. 5. Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, TX. 6. Department of Obstetrics and Gynecology, University of Vermont, Burlington, VT. 7. Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI. 8. Department of Biostatistics, Yale University School of Public Health, New Haven, CT. 9. Department of Obstetrics and Gynecology, University of Oklahoma College of Medicine, Oklahoma City, OK. 10. Stanford University Medical Center, Stanford, CA. 11. Carolinas Medical Center, Charlotte, NC. 12. Rutgers New Jersey Medical School, University of Alabama at Birmingham, Birmingham, AL. 13. University of Alabama at Birmingham, Birmingham, AL. 14. Department of Reproductive Endocrinology and Infertility, University of California, San Francisco, San Francisco, CA. 15. Ligand Core Laboratory, University of Virginia Center for Research in Reproduction, Charlottesville, VA. 16. Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI. 17. Upstate University Hospital, Syracuse, NY. 18. Fertility and Infertility Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD.
Abstract
BACKGROUND: While female sexual dysfunction is a frequent occurrence, characteristics in infertile women are not well delineated. Furthermore, the impact of infertility etiology on the characteristics in women with differing androgen levels observed in women with polycystic ovary syndrome and unexplained infertility has not been assessed. OBJECTIVE: The objective of the study was to determine the characteristics of sexual dysfunction in women with polycystic ovary syndrome and unexplained infertility. STUDY DESIGN: A secondary data analysis was performed on 2 of Eunice Kennedy Shriver National Institute of Child Health and Human Development Cooperative Reproductive Medicine Networks clinical trials: Pregnancy in Polycystic Ovary Syndrome Study II and Assessment of Multiple Intrauterine Gestations From Ovarian Stimulation. Both protocols assessed female sexual function using the Female Sexual Function Inventory and the Female Sexual Distress Scale. RESULTS: Women with polycystic ovary syndrome had higher weight and body mass index than women with unexplained infertility (each P < .001), greater phenotypic (Ferriman-Gallwey hirsutism score, sebum score, and acne score; each P < .001), and hormonal (testosterone, free testosterone, and dehydroepiandrosterone; each P < .001) evidence of androgen excess. Sexual function scores, as assessed by the Female Sexual Function Inventory, were nearly identical. The Female Sexual Distress Scale total score was higher in women with polycystic ovary syndrome. The mean Female Sexual Function Inventory total score increased slightly as the free androgen index increased, mainly as a result of the desire subscore. This association was more pronounced in the women with unexplained infertility. CONCLUSION: Reproductive-age women with infertility associated with polycystic ovary syndrome and unexplained infertility, despite phenotypic and biochemical differences in androgenic manifestations, do not manifest clinically significant differences in sexual function.
BACKGROUND: While female sexual dysfunction is a frequent occurrence, characteristics in infertile women are not well delineated. Furthermore, the impact of infertility etiology on the characteristics in women with differing androgen levels observed in women with polycystic ovary syndrome and unexplained infertility has not been assessed. OBJECTIVE: The objective of the study was to determine the characteristics of sexual dysfunction in women with polycystic ovary syndrome and unexplained infertility. STUDY DESIGN: A secondary data analysis was performed on 2 of Eunice Kennedy Shriver National Institute of Child Health and Human Development Cooperative Reproductive Medicine Networks clinical trials: Pregnancy in Polycystic Ovary Syndrome Study II and Assessment of Multiple Intrauterine Gestations From Ovarian Stimulation. Both protocols assessed female sexual function using the Female Sexual Function Inventory and the Female Sexual Distress Scale. RESULTS:Women with polycystic ovary syndrome had higher weight and body mass index than women with unexplained infertility (each P < .001), greater phenotypic (Ferriman-Gallwey hirsutism score, sebum score, and acne score; each P < .001), and hormonal (testosterone, free testosterone, and dehydroepiandrosterone; each P < .001) evidence of androgen excess. Sexual function scores, as assessed by the Female Sexual Function Inventory, were nearly identical. The Female Sexual Distress Scale total score was higher in women with polycystic ovary syndrome. The mean Female Sexual Function Inventory total score increased slightly as the free androgen index increased, mainly as a result of the desire subscore. This association was more pronounced in the women with unexplained infertility. CONCLUSION: Reproductive-age women with infertility associated with polycystic ovary syndrome and unexplained infertility, despite phenotypic and biochemical differences in androgenic manifestations, do not manifest clinically significant differences in sexual function.
Authors: Richard S Legro; Allen R Kunselman; Robert G Brzyski; Peter R Casson; Michael P Diamond; William D Schlaff; Gregory M Christman; Christos Coutifaris; Hugh S Taylor; Esther Eisenberg; Nanette Santoro; Heping Zhang Journal: Contemp Clin Trials Date: 2012-01-13 Impact factor: 2.226
Authors: Richard S Legro; Robert G Brzyski; Michael P Diamond; Christos Coutifaris; William D Schlaff; Ruben Alvero; Peter Casson; Gregory M Christman; Hao Huang; Qingshang Yan; Daniel J Haisenleder; Kurt T Barnhart; G Wright Bates; Rebecca Usadi; Richard Lucidi; Valerie Baker; J C Trussell; Stephen A Krawetz; Peter Snyder; Dana Ohl; Nanette Santoro; Esther Eisenberg; Heping Zhang Journal: Fertil Steril Date: 2013-10-21 Impact factor: 7.329
Authors: Suzanne L West; Aimee A D'Aloisio; Robert P Agans; William D Kalsbeek; Natalie N Borisov; John M Thorp Journal: Arch Intern Med Date: 2008-07-14
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Authors: Nik Hussain Nik Hazlina; Mohd Noor Norhayati; Ismail Shaiful Bahari; Nik Ahmad Nik Muhammad Arif Journal: BMJ Open Date: 2022-03-30 Impact factor: 2.692
Authors: Antonio Aversa; Sandro La Vignera; Rocco Rago; Alessandra Gambineri; Rossella E Nappi; Aldo E Calogero; Alberto Ferlin Journal: Front Endocrinol (Lausanne) Date: 2020-08-11 Impact factor: 5.555