Hualiang Lin1, Yanfei Guo2, Yang Zheng2, Xing Zhao3, Zheng Cao4, Steven E Rigdon5, Hong Xian5, Xing Li1, Tao Liu1, Jianpeng Xiao1, Weilin Zeng1, Nancy L Weaver5, ZhengminMin Qian6, Wenjun Ma7, Fan Wu8. 1. Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China. 2. Shanghai Municipal Centre for Disease Control and Prevention, Shanghai, China. 3. West China School of Public Health, Sichuan University, Chengdu, China. 4. Guangzhou Institute of Geochemistry, Chinese Academy of Science, Guangzhou 510640, China. 5. Saint Louis University College for Public Health & Social Justice, St. Louis, MO, USA. 6. Saint Louis University College for Public Health & Social Justice, St. Louis, MO, USA. Electronic address: zqian2@slu.edu. 7. Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China. Electronic address: mawj@gdiph.org.cn. 8. Shanghai Municipal Centre for Disease Control and Prevention, Shanghai, China. Electronic address: wufan@scdc.sh.cn.
Abstract
BACKGROUND: Exposure to particulate matter pollution is associated with various cardiopulmonary diseases, which are closely related with disability. The direct relationship between air pollution and disability, however, has not been fully explored. METHODS: We used data from 45,625 participants in the Study on global AGEing and adult health in six low- and middle-income countries. The 12-item version of the World Health Organization Disability Assessment Schedule (WHODAS 2.0) was used to measure the disability with six domains (cognition, mobility, self-care, getting along, life activities, and participation in society). Participants' community addresses were used to estimate annual concentration of PM2.5 using satellite data. We used linear mixed models to examine the effects of PM2.5 on overall and domain-specific WHODAS scores. RESULTS: Exposure to PM2.5 was significantly associated with greater disability score (a higher score implies a greater disability); each 10μg/m3 increase corresponded to 0.72 (95% CI: 0.22, 1.22) increase in overall disability score. Compared with low PM2.5 level (<14.33μg/m3), moderate (14.33-27.83μg/m3) and high exposure levels (>27.83μg/m3) were associated with 3.43 (95% CI: 1.43, 5.43) and 3.72 (95% CI: 1.59, 5.86) increase in disability scores. Among the six domains, cognition, mobility and getting along were found to be associated with PM2.5. Stratified analyses found that women and older subjects were more sensitive to this effect. CONCLUSION: Exposure to ambient PM2.5 might be one risk factor of disability in the low- and middle-income countries, women and older adults are the vulnerable population; and among the six domains, cognition, mobility and getting along are more relevant to this effect.
BACKGROUND: Exposure to particulate matter pollution is associated with various cardiopulmonary diseases, which are closely related with disability. The direct relationship between air pollution and disability, however, has not been fully explored. METHODS: We used data from 45,625 participants in the Study on global AGEing and adult health in six low- and middle-income countries. The 12-item version of the World Health Organization Disability Assessment Schedule (WHODAS 2.0) was used to measure the disability with six domains (cognition, mobility, self-care, getting along, life activities, and participation in society). Participants' community addresses were used to estimate annual concentration of PM2.5 using satellite data. We used linear mixed models to examine the effects of PM2.5 on overall and domain-specific WHODAS scores. RESULTS: Exposure to PM2.5 was significantly associated with greater disability score (a higher score implies a greater disability); each 10μg/m3 increase corresponded to 0.72 (95% CI: 0.22, 1.22) increase in overall disability score. Compared with low PM2.5 level (<14.33μg/m3), moderate (14.33-27.83μg/m3) and high exposure levels (>27.83μg/m3) were associated with 3.43 (95% CI: 1.43, 5.43) and 3.72 (95% CI: 1.59, 5.86) increase in disability scores. Among the six domains, cognition, mobility and getting along were found to be associated with PM2.5. Stratified analyses found that women and older subjects were more sensitive to this effect. CONCLUSION: Exposure to ambient PM2.5 might be one risk factor of disability in the low- and middle-income countries, women and older adults are the vulnerable population; and among the six domains, cognition, mobility and getting along are more relevant to this effect.
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