Nilminie Rathnayake1, Kåre Buhlin1, Barbro Kjellström2, Bjorn Klinge1,3, Christian Löwbeer4,5, Anna Norhammar2,6, Lars Rydén2, Timo Sorsa1,7, Taina Tervahartiala7, Anders Gustafsson1. 1. Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Solna, Sweden. 2. Cardiology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Solna, Sweden. 3. Department of Periodontology, Faculty of Odontology, Malmö University, Malmö, Sweden. 4. Department of Clinical Chemistry, Aleris Medilab, Täby, Sweden. 5. Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden. 6. Cardiology Unit, Capio S:t Görans Hospital, Stockholm, Sweden. 7. Helsinki University Central Hospital, Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.
Abstract
AIM: To relate cardiac biomarkers, such as cystatin C and growth differentiation factor-15 (GDF-15) in saliva to myocardial infarction (MI) and to periodontal status, and to investigate the relation between salivary and plasma cardiac biomarkers. MATERIALS AND METHODS: Two hundred patients with MI admitted to coronary care units and 200 matched controls without MI were included. Dental examination and collection of blood and saliva samples was performed 6-10 weeks after the MI for patients and in close proximity thereafter for controls. Analysing methods: ARCHITECT i4000SR, Immulite 2000 XPi or ELISA. RESULTS: The mean age was 62 ± 8 years and 84% were male. Total probing pocket depth, fibrinogen, white blood cell counts and HbA1c were higher in patients than controls. GDF-15 levels correlated with most of the included clinical variables in both study groups. No correlation was found between plasma and saliva levels of cystatin C or GDF-15. CONCLUSION: Salivary cystatin C and GDF-15 could not differentiate between MI patients and controls.
AIM: To relate cardiac biomarkers, such as cystatin C and growth differentiation factor-15 (GDF-15) in saliva to myocardial infarction (MI) and to periodontal status, and to investigate the relation between salivary and plasma cardiac biomarkers. MATERIALS AND METHODS: Two hundred patients with MI admitted to coronary care units and 200 matched controls without MI were included. Dental examination and collection of blood and saliva samples was performed 6-10 weeks after the MI for patients and in close proximity thereafter for controls. Analysing methods: ARCHITECT i4000SR, Immulite 2000 XPi or ELISA. RESULTS: The mean age was 62 ± 8 years and 84% were male. Total probing pocket depth, fibrinogen, white blood cell counts and HbA1c were higher in patients than controls. GDF-15 levels correlated with most of the included clinical variables in both study groups. No correlation was found between plasma and saliva levels of cystatin C or GDF-15. CONCLUSION:Salivarycystatin C and GDF-15 could not differentiate between MI patients and controls.
Authors: Hanna Lähteenmäki; Taina Tervahartiala; Ismo T Räisänen; Pirjo Pärnänen; Matti Mauramo; Shipra Gupta; Victoria Sampson; Nilminie Rathnayake; Anna-Maria Heikkinen; Saeed Alassiri; Dirk-Rolf Gieselmann; Roland Frankenberger; Timo Sorsa Journal: Clin Exp Dent Res Date: 2022-02-03