Literature DB >> 28453491

Neurofibrillary Tangles of Aβx-40 in Alzheimer's Disease Brains.

Ana-María Lacosta, Daniel Insua, Hassnae Badi, Pedro Pesini, Manuel Sarasa.   

Abstract

The two pathognomonic lesions in the brain of AD patients are senile plaques and intraneuronal neurofibrillary tangles (NFT). Previous studies have demonstrated that amyloid-β (Aβ) is a component of both senile plaques and NFTs, and have showed that intracellular accumulation of Aβ is toxic for cells and precedes the appearance of extracellular amyloid deposits. Here we report that there are numerous intraneuronal NFT and extraneuronal NFT immunoreactive for Aβx-40 in which there is no co-localization with tau staining suggesting the existence of two different neurodegenerating populations associated with the intracellular accumulation of either tau protein or Aβx-40 in AD.

Entities:  

Keywords:  Amyloid-β; Aβ peptides; immunohistochemistry; neurodegeneration; phosphorylated-tau; tau protein

Mesh：

Substances：

Year:  2017        PMID： 28453491     DOI： 10.3233/JAD-170163

Source DB:  PubMed          Journal:  J Alzheimers Dis        ISSN： 1387-2877            Impact factor:   4.472


  8 in total

1.  miR‑199a decreases Neuritin expression involved in the development of Alzheimer's disease in APP/PS1 mice.

Authors:  Dandan Song; Guoxiang Li; Yu Hong; Pan Zhang; Jingling Zhu; Lei Yang; Jin Huang
Journal:  Int J Mol Med       Date:  2020-05-12       Impact factor: 4.101

Review 2.  Peptide-Based Vaccines: Current Progress and Future Challenges.

Authors:  Ryan J Malonis; Jonathan R Lai; Olivia Vergnolle
Journal:  Chem Rev       Date:  2019-12-05       Impact factor: 60.622

3.  Yuan‑zhi‑san inhibits tau protein aggregation in an Aβ1‑40‑induced Alzheimer's disease rat model via the ubiquitin‑proteasome system.

Authors:  Bin Li; Pei-Jun Xie; Yan-Wei Hao; Yu Guo; Jun-Rong Yu; Dao-Yin Gong; Jing Guo; Jin-Hao Zeng; Yi Zhang
Journal:  Mol Med Rep       Date:  2021-02-19       Impact factor: 2.952

4.  Changes in cognitive function and related brain regions in chronic benzene poisoning: a case report.

Authors:  Jiaojiao Hu; Enyan Yu; Zhengluan Liao
Journal:  Ann Transl Med       Date:  2021-01

5.  A meta-analysis of cohort studies: Traumatic brain injury and risk of Alzheimer's Disease.

Authors:  Jieyu Zhang; Yongkang Zhang; Juntao Zou; Fei Cao
Journal:  PLoS One       Date:  2021-06-22       Impact factor: 3.240

6.  Safety, tolerability and immunogenicity of an active anti-Aβ40 vaccine (ABvac40) in patients with Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase I trial.

Authors:  Ana-María Lacosta; María Pascual-Lucas; Pedro Pesini; Diego Casabona; Virginia Pérez-Grijalba; Iván Marcos-Campos; Leticia Sarasa; Jesus Canudas; Hassnae Badi; Inmaculada Monleón; Itziar San-José; Josep Munuera; Octavio Rodríguez-Gómez; Carla Abdelnour; Asunción Lafuente; Mar Buendía; Mercè Boada; Lluis Tárraga; Agustín Ruiz; Manuel Sarasa
Journal:  Alzheimers Res Ther       Date:  2018-01-29       Impact factor: 6.982

Review 7.  The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases.

Authors:  Wioletta Rozpędek-Kamińska; Natalia Siwecka; Adam Wawrzynkiewicz; Radosław Wojtczak; Dariusz Pytel; J Alan Diehl; Ireneusz Majsterek
Journal:  Int J Mol Sci       Date:  2020-03-19       Impact factor: 5.923

Review 8.  Oligomerization and Conformational Change Turn Monomeric β-Amyloid and Tau Proteins Toxic: Their Role in Alzheimer's Pathogenesis.

Authors:  Botond Penke; Mária Szűcs; Ferenc Bogár
Journal:  Molecules       Date:  2020-04-03       Impact factor: 4.411
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.