Literature DB >> 2845309

Synthetic omega-conotoxin blocks synaptic transmission in the hippocampus in vitro.

H Kamiya1, S Sawada, C Yamamoto.   

Abstract

The effects of some organic calcium channel blockers and a toxin on synaptic transmission were examined in hippocampal slices from the guinea pig. omega-Conotoxin fraction GVIA, a novel peptide that blocks N and L type voltage-sensitive calcium channels, blocked synaptic transmission from mossy fibers to CA3 neurons at very low concentration (100 nM). However, organic calcium channel blockers such as verapamil (100 microM) and nifedipine (10 microM), which block L type calcium channels, had little effect on the synaptic transmission. Phenytoin (100 microM, T type calcium channel blocker) was also ineffective to block the synaptic transmission. These results suggest that presynaptic calcium channels which cause transmitter release may be N type calcium channel.

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Year:  1988        PMID： 2845309     DOI： 10.1016/0304-3940(88)90253-4

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  20 in total

1.  Dual mechanism for presynaptic modulation by axonal metabotropic glutamate receptor at the mouse mossy fibre-CA3 synapse.

Authors:  H Kamiya; S Ozawa
Journal:  J Physiol       Date:  1999-07-15       Impact factor: 5.182

2.  Nimodipine and nifedipine enhance transmission at the Schaffer collateral CA1 pyramidal neuron synapse.

Authors:  M H O'Regan; J D Kocsis; S G Waxman
Journal:  Exp Brain Res       Date:  1991       Impact factor: 1.972

3.  Characterizing the site and mode of action of dynorphin at hippocampal mossy fiber synapses in the guinea pig.

Authors:  P E Castillo; P A Salin; M G Weisskopf; R A Nicoll
Journal:  J Neurosci       Date:  1996-10-01       Impact factor: 6.167

Review 4.  Activity-dependent changes in voltage-dependent calcium currents and transmitter release.

Authors:  G A Lnenicka; S J Hong
Journal:  Mol Neurobiol       Date:  1997 Feb-Apr       Impact factor: 5.590

5.  Activation of metabotropic glutamate receptor type 2/3 suppresses transmission at rat hippocampal mossy fibre synapses.

Authors:  H Kamiya; H Shinozaki; C Yamamoto
Journal:  J Physiol       Date:  1996-06-01       Impact factor: 5.182

6.  Developmentally regulated actions of alcohol on hippocampal glutamatergic transmission.

Authors:  Manuel Mameli; Paula A Zamudio; Mario Carta; C Fernando Valenzuela
Journal:  J Neurosci       Date:  2005-08-31       Impact factor: 6.167

7.  Prolonged attenuation of amygdala-kindled seizure measures in rats by convection-enhanced delivery of the N-type calcium channel antagonists omega-conotoxin GVIA and omega-conotoxin MVIIA.

Authors:  Maciej Gasior; Natalie A White; Michael A Rogawski
Journal:  J Pharmacol Exp Ther       Date:  2007-08-23       Impact factor: 4.030

8.  L-Type calcium channels mediate a slow excitatory synaptic transmission in rat midbrain dopaminergic neurons.

Authors:  A Bonci; P Grillner; N B Mercuri; G Bernardi
Journal:  J Neurosci       Date:  1998-09-01       Impact factor: 6.167

9.  Presynaptic L-Type Ca2+ Channels Increase Glutamate Release Probability and Excitatory Strength in the Hippocampus during Chronic Neuroinflammation.

Authors:  Giorgia Giansante; Antonella Marte; Alessandra Romei; Cosimo Prestigio; Franco Onofri; Fabio Benfenati; Pietro Baldelli; Pierluigi Valente
Journal:  J Neurosci       Date:  2020-08-03       Impact factor: 6.167

10.  The effect of omega-conotoxin GVIA on synaptic transmission within the nucleus accumbens and hippocampus of the rat in vitro.

Authors:  A L Horne; J A Kemp
Journal:  Br J Pharmacol       Date:  1991-07       Impact factor: 8.739
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