Literature DB >> 28450717

FDA approves first deuterated drug.

Asher Mullard.   

Abstract

Year:  2017        PMID： 28450717     DOI： 10.1038/nrd.2017.89

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


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  7 in total

1.  Glucocorticoid receptor modulators CpdX and CpdX-D3 exhibit the same in vivo antiinflammatory activities as synthetic glucocorticoids.

Authors:  Guoqiang Hua; Naimah Zein; François Daubeuf; Pierre Chambon
Journal:  Proc Natl Acad Sci U S A       Date:  2019-06-21       Impact factor: 11.205

2.  From methylene bridged diindole to carbonyl linked benzimidazoleindole: Development of potent and metabolically stable PCSK9 modulators.

Authors:  Haibo Xie; Ka Yang; Gabrielle N Winston-McPherson; Donnie S Stapleton; Mark P Keller; Alan D Attie; Kerry A Smith; Weiping Tang
Journal:  Eur J Med Chem       Date:  2020-08-04       Impact factor: 6.514

3.  Bioinspired design of a robust d 3-methylating agent.

Authors:  Minyan Wang; Yunfei Zhao; Yue Zhao; Zhuangzhi Shi
Journal:  Sci Adv       Date:  2020-05-08       Impact factor: 14.136

4.  Deuteration enhances the anti-tumor effects and relative anti-inflammatory effects via affecting proliferation and apoptosis.

Authors:  Ao Li; Xiaojiao Wang; Danni Li; Xiaohong Li; Rou Li; Xuejuan Yang; Xiao Li
Journal:  Heliyon       Date:  2021-03-08

Review 5.  Impaired antioxidant KEAP1-NRF2 system in amyotrophic lateral sclerosis: NRF2 activation as a potential therapeutic strategy.

Authors:  Silvia Bono; Marco Feligioni; Massimo Corbo
Journal:  Mol Neurodegener       Date:  2021-10-18       Impact factor: 14.195

6.  Total Synthesis and Metabolic Stability of Hispidulin and Its d-Labelled Derivative.

Authors:  Liang-Chieh Chen; Kai-Cheng Hsu; Lih-Chu Chiou; Hui-Ju Tseng; Wei-Jan Huang
Journal:  Molecules       Date:  2017-11-04       Impact factor: 4.411

7.  Palladium-Catalyzed Nondirected Late-Stage C-H Deuteration of Arenes.

Authors:  Mirxan Farizyan; Arup Mondal; Sourjya Mal; Fritz Deufel; Manuel van Gemmeren
Journal:  J Am Chem Soc       Date:  2021-09-28       Impact factor: 15.419
  7 in total

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