| Literature DB >> 28450643 |
Pablo Librado1, Cristina Gamba1, Charleen Gaunitz1, Clio Der Sarkissian1, Mélanie Pruvost2, Anders Albrechtsen3, Antoine Fages1,4, Naveed Khan1,5, Mikkel Schubert1, Vidhya Jagannathan6, Aitor Serres-Armero7,8, Lukas F K Kuderna7,8, Inna S Povolotskaya7,8, Andaine Seguin-Orlando1,9, Sébastien Lepetz10, Markus Neuditschko11, Catherine Thèves4, Saleh Alquraishi12, Ahmed H Alfarhan12, Khaled Al-Rasheid12, Stefan Rieder11, Zainolla Samashev13, Henri-Paul Francfort14, Norbert Benecke15, Michael Hofreiter16, Arne Ludwig17, Christine Keyser4,18, Tomas Marques-Bonet7,8,19, Bertrand Ludes4,20, Eric Crubézy4, Tosso Leeb6, Eske Willerslev1, Ludovic Orlando21,4.
Abstract
The genomic changes underlying both early and late stages of horse domestication remain largely unknown. We examined the genomes of 14 early domestic horses from the Bronze and Iron Ages, dating to between ~4.1 and 2.3 thousand years before present. We find early domestication selection patterns supporting the neural crest hypothesis, which provides a unified developmental origin for common domestic traits. Within the past 2.3 thousand years, horses lost genetic diversity and archaic DNA tracts introgressed from a now-extinct lineage. They accumulated deleterious mutations later than expected under the cost-of-domestication hypothesis, probably because of breeding from limited numbers of stallions. We also reveal that Iron Age Scythian steppe nomads implemented breeding strategies involving no detectable inbreeding and selection for coat-color variation and robust forelimbs.Entities:
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Year: 2017 PMID： 28450643 DOI： 10.1126/science.aam5298
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728