Literature DB >> 2844969

Ribonucleotide reductase encoded by herpes simplex virus is a determinant of the pathogenicity of the virus in mice and a valid antiviral target.

J M Cameron1, I McDougall, H S Marsden, V G Preston, D M Ryan, J H Subak-Sharpe.   

Abstract

The role of the herpes simplex virus (HSV)-encoded ribonucleotide reductase (RR) in the pathogenicity of the virus has been examined by use of mutants with lesions in either the large or small subunit of the enzyme. The virulence of the mutants in mice was reduced by about 10(6)-fold when compared with that of the parental virus (HSV type 1 strain 17), while the virulence of a revertant of one of the mutants was restored to within about 100-fold of that of the parent virus. These experiments demonstrate that activity of the HSV RR is essential for virus pathogenicity in mice and suggests that the enzyme is a valid target for specific antiviral compounds.

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Year:  1988        PMID： 2844969     DOI： 10.1099/0022-1317-69-10-2607

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  46 in total

1.  Herpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir.

Authors:  D M Coen; D J Goldstein; S K Weller
Journal:  Antimicrob Agents Chemother       Date:  1989-08       Impact factor: 5.191

2.  Expression of an altered ribonucleotide reductase activity associated with the replication of murine cytomegalovirus in quiescent fibroblasts.

Authors:  D Lembo; G Gribaudo; A Hofer; L Riera; M Cornaglia; A Mondo; A Angeretti; M Gariglio; L Thelander; S Landolfo
Journal:  J Virol       Date:  2000-12       Impact factor: 5.103

3.  Herpes simplex virus type 1 dUTPase mutants are attenuated for neurovirulence, neuroinvasiveness, and reactivation from latency.

Authors:  R B Pyles; N M Sawtell; R L Thompson
Journal:  J Virol       Date:  1992-11       Impact factor: 5.103

Review 4.  Herpes simplex virus-based vectors.

Authors:  Robin Lachmann
Journal:  Int J Exp Pathol       Date:  2004-10       Impact factor: 1.925

5.  Genomic sequences homologous to the protein kinase region of the bifunctional herpes simplex virus type 2 protein ICP10.

Authors:  C C Smith; J P Wymer; J Luo; L Aurelian
Journal:  Virus Genes       Date:  1991-07       Impact factor: 2.332

6.  The Epstein-Barr virus (EBV) deubiquitinating enzyme BPLF1 reduces EBV ribonucleotide reductase activity.

Authors:  Christopher B Whitehurst; Shunbin Ning; Gretchen L Bentz; Florent Dufour; Edward Gershburg; Julia Shackelford; Yves Langelier; Joseph S Pagano
Journal:  J Virol       Date:  2009-02-25       Impact factor: 5.103

7.  Construction and characterization of a herpes simplex virus type 1 mutant unable to transinduce immediate-early gene expression.

Authors:  C I Ace; T A McKee; J M Ryan; J M Cameron; C M Preston
Journal:  J Virol       Date:  1989-05       Impact factor: 5.103

8.  Synergistic therapy by acyclovir and A1110U for mice orofacially infected with herpes simplex viruses.

Authors:  M N Ellis; D C Lobe; T Spector
Journal:  Antimicrob Agents Chemother       Date:  1989-10       Impact factor: 5.191

9.  Pathogenicity and vaccine efficacy of a thymidine kinase-deficient mutant of feline herpesvirus type 1 in cats.

Authors:  N Yokoyama; K Maeda; Y Tohya; Y Kawaguchi; Y S Shin; M Ono; S Ishiguro; Y Fujikawa; T Mikami
Journal:  Arch Virol       Date:  1996       Impact factor: 2.574

10.  Vaccinia virus-encoded ribonucleotide reductase subunits are differentially required for replication and pathogenesis.

Authors:  Don B Gammon; Branawan Gowrishankar; Sophie Duraffour; Graciela Andrei; Chris Upton; David H Evans
Journal:  PLoS Pathog       Date:  2010-07-08       Impact factor: 6.823
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