Lili Hou1, Fen Gu2, Guanghui Gao3, Caicun Zhou3. 1. Department of Nursing, Shanghai Pulmonary Hospital of Tongji University, Shanghai 200043, China. 2. Respiratory Department, Shanghai Pulmonary Hospital of Tongji University, Shanghai 200043, China. 3. Department of Oncology, Shanghai Pulmonary Hospital of Tongji University, Shanghai 200043, China.
Abstract
BACKGROUND: To investigate the effect of percutaneous electrical stimulation on chemotherapy-induced bone marrow suppression in patients with lung cancer. METHODS:From December 2014 to August 2015, one hundred ninety-one non-small cell lung cancer patients with chemotherapy naive were randomly divided into control group, medication group, and transcutaneous electrical acupoint stimulation (TEAS) group. Patients with the control group received routine nursing care, the medication group was treated by oral administration of prophylactic agents, and TEAS group received electrical stimulation of acupoints including Dazhui (DU14), Geshu (BL17), Zusanli (ST36), Sanyinjiao (SP6), and Hegu (LI4). The primary end point was the blood routine indexes and secondary end point was the degree of comfort. RESULTS: The white blood cell in the TEAS group was significantly higher than the control group on day 8 and day 14 (P<0.05). The platelet count in the TEAS group was significantly higher than control group on day 5, day 8 and day 11 (P<0.05). The comfort score in the TEAS group was significantly higher than control group on day 8 (P<0.05). CONCLUSIONS:Percutaneous electrical stimulation of acupoints could prevent chemotherapy-induced bone marrow suppression in lung cancer patients and ensure a smooth continuation of chemotherapy.
RCT Entities:
BACKGROUND: To investigate the effect of percutaneous electrical stimulation on chemotherapy-induced bone marrow suppression in patients with lung cancer. METHODS: From December 2014 to August 2015, one hundred ninety-one non-small cell lung cancerpatients with chemotherapy naive were randomly divided into control group, medication group, and transcutaneous electrical acupoint stimulation (TEAS) group. Patients with the control group received routine nursing care, the medication group was treated by oral administration of prophylactic agents, and TEAS group received electrical stimulation of acupoints including Dazhui (DU14), Geshu (BL17), Zusanli (ST36), Sanyinjiao (SP6), and Hegu (LI4). The primary end point was the blood routine indexes and secondary end point was the degree of comfort. RESULTS: The white blood cell in the TEAS group was significantly higher than the control group on day 8 and day 14 (P<0.05). The platelet count in the TEAS group was significantly higher than control group on day 5, day 8 and day 11 (P<0.05). The comfort score in the TEAS group was significantly higher than control group on day 8 (P<0.05). CONCLUSIONS: Percutaneous electrical stimulation of acupoints could prevent chemotherapy-induced bone marrow suppression in lung cancerpatients and ensure a smooth continuation of chemotherapy.
Entities:
Keywords:
Acupoint; bone marrow suppression; chemotherapy; electrical stimulation; lung cancer
Authors: Bjørn H Grønberg; Stein Sundstrøm; Stein Kaasa; Roy M Bremnes; Oystein Fløtten; Tore Amundsen; Harald H Hjelde; Christian von Plessen; Marit Jordhøy Journal: Eur J Cancer Date: 2010-05-12 Impact factor: 9.162
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