S Nagai1, M Kawai1, M Myowa-Yamakoshi2, T Morimoto3, T Matsukura1, T Heike1. 1. Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan. 2. Graduate School of Education, Kyoto University, Kyoto, Japan. 3. Department of Clinical Epidemiology, Hyogo College of Medicine, Hyogo, Japan.
Abstract
OBJECTIVE: The objective of this study was to estimate gonadotropin concentrations in small for gestational age (SGA) male infants with the reactivation of the hypothalamic-pituitary-gonadal axis during the first few months of life that is important for genital development. STUDY DESIGN: We prospectively examined 15 SGA and 15 appropriate for gestational age (AGA) preterm male infants between 2013 and 2014 at Kyoto University Hospital. Gonadotropin concentrations (luteinizing hormone (LH) and follicle-stimulating hormone (FSH)) were measured in serial urine samples from the postnatal days 7 to 168 and compared between SGA and AGA infants using the Mann-Whitney test. RESULTS: A longitudinal analysis showed that SGA infants had higher LH and lower FSH concentrations (P=0.004 and P=0.006, respectively) than AGA infants. CONCLUSION: Male infants who are SGA at birth because of fetal growth restriction have gonadotropin secretion abnormalities in the first few months of life.
OBJECTIVE: The objective of this study was to estimate gonadotropin concentrations in small for gestational age (SGA) male infants with the reactivation of the hypothalamic-pituitary-gonadal axis during the first few months of life that is important for genital development. STUDY DESIGN: We prospectively examined 15 SGA and 15 appropriate for gestational age (AGA) preterm male infants between 2013 and 2014 at Kyoto University Hospital. Gonadotropin concentrations (luteinizing hormone (LH) and follicle-stimulating hormone (FSH)) were measured in serial urine samples from the postnatal days 7 to 168 and compared between SGA and AGA infants using the Mann-Whitney test. RESULTS: A longitudinal analysis showed that SGA infants had higher LH and lower FSH concentrations (P=0.004 and P=0.006, respectively) than AGA infants. CONCLUSION: Male infants who are SGA at birth because of fetal growth restriction have gonadotropin secretion abnormalities in the first few months of life.
Authors: Lourdes Ibáñez; Carme Valls; Maria Cols; Angela Ferrer; Maria Victoria Marcos; Francis De Zegher Journal: J Clin Endocrinol Metab Date: 2002-05 Impact factor: 5.958
Authors: Yoav Yinon; John C P Kingdom; Leslie K Proctor; Edmond N Kelly; Joao L Pippi Salle; Diane Wherrett; Sarah Keating; Ori Nevo; David Chitayat Journal: Am J Med Genet A Date: 2010-01 Impact factor: 2.802
Authors: P Beck-Peccoz; V Padmanabhan; A M Baggiani; D Cortelazzi; M Buscaglia; G Medri; A M Marconi; G Pardi; I Z Beitins Journal: J Clin Endocrinol Metab Date: 1991-09 Impact factor: 5.958
Authors: Lucia Lanciotti; Marta Cofini; Alberto Leonardi; Laura Penta; Susanna Esposito Journal: Front Endocrinol (Lausanne) Date: 2018-07-23 Impact factor: 5.555