Literature DB >> 28447583

Prevalence and Clinical Significance of Diabetes in Asian Versus White Patients With Heart Failure.

Ingrid E M Bank1, Crystel M Gijsberts2, Tiew-Hwa K Teng3, Lina Benson4, David Sim3, Poh Shuan Daniel Yeo5, Hean Yee Ong6, Fazlur Jaufeerally7, Gerard K T Leong8, Lieng H Ling9, A Mark Richards10, Dominique P V de Kleijn11, Ulf Dahlström12, Lars H Lund13, Carolyn S P Lam14.   

Abstract

OBJECTIVES: The study sought to compare the prevalence, clinical correlates and prognostic impact of diabetes in Southeast Asian versus white patients with heart failure (HF) with preserved or reduced ejection fraction.
BACKGROUND: Diabetes mellitus is common in HF and is associated with impaired prognosis. Asia is home to the majority of the world's diabetic population, yet data on the prevalence and clinical significance of diabetes in Asian patients with HF are sparse, and no studies have directly compared Asian and white patients.
METHODS: Two contemporary population-based HF cohorts were combined: from Singapore (n = 1,002, median [25th to 75th percentile] age 62 [54 to 70] years, 76% men, 19.5% obesity) and Sweden (n = 19,537, 77 [68 to 84] years, 60% men, 24.8% obesity). The modifying effect of ethnicity on the relationship between diabetes and clinical correlates or prognosis (HF hospitalization and all-cause mortality) was examined using interaction terms.
RESULTS: Diabetes was present in 569 (57%) Asian patients versus 4,680 (24%) white patients (p < 0.001). Adjusting for clinical covariates, obesity was more strongly associated with diabetes in white patients (odds ratio [OR]: 3.45; 95% confidence interval [CI]: 2.86 to 4.17) than in Asian patients (OR: 1.82; 95% CI: 1.13 to 2.96; pinteraction = 0.026). Diabetes was more strongly associated with increased HF hospitalization and all-cause mortality in Asian patients (hazard ratio: 1.50; 95% CI: 1.21 to 1.87) than in white patients (hazard ratio: 1.29; 95% CI: 1.22 to 1.36; pinteraction = 0.045).
CONCLUSIONS: Diabetes was 3-fold more common in Southeast Asian compared to white patients with HF, despite younger age and less obesity, and more strongly associated with poor outcomes in Asian patients than white patients. These results underscore the importance of ethnicity-tailored aggressive strategies to prevent diabetes and its complications.
Copyright © 2017 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  diabetes mellitus; global disease patterns; global health; heart failure with preserved ejection fraction; heart failure with reduced ejection fraction

Mesh:

Year:  2017        PMID: 28447583     DOI: 10.1016/j.jchf.2016.09.015

Source DB:  PubMed          Journal:  JACC Heart Fail        ISSN: 2213-1779            Impact factor:   12.035


  14 in total

1.  Real-World Eligibility for Sacubitril/Valsartan in Heart Failure with Reduced Ejection Fraction Patients in Korea: Data from the Korean Acute Heart Failure (KorAHF) Registry.

Authors:  Jaewon Oh; Chan Joo Lee; Jin Joo Park; Sang Eun Lee; Min-Seok Kim; Hyun-Jai Cho; Jin-Oh Choi; Hae-Young Lee; Kyung-Kuk Hwang; Kye Hun Kim; Byung-Su Yoo; Dong-Ju Choi; Sang Hong Baek; Eun-Seok Jeon; Jae-Joong Kim; Myeong-Chan Cho; Shung Chull Chae; Byung-Hee Oh; Seok-Min Kang
Journal:  Int J Heart Fail       Date:  2019-10-24

Review 2.  Clinical correlates and pharmacological management of Asian patients with concomitant diabetes mellitus and heart failure.

Authors:  Yvonne May Fen Chia; Tiew-Hwa Katherine Teng; Chanchal Chandramouli; Jonathan Yap; Michael MacDonald; Carolyn S P Lam
Journal:  Heart Fail Rev       Date:  2018-05       Impact factor: 4.214

3.  Differential left ventricular and left atrial remodelling in heart failure with preserved ejection fraction patients with and without diabetes.

Authors:  Gaurav S Gulsin; Prathap Kanagala; Daniel C S Chan; Adrian S H Cheng; Lavanya Athithan; Matthew P M Graham-Brown; Anvesha Singh; Jing Yang; Zhuyin Li; Kamlesh Khunti; Melanie J Davies; Jayanth R Arnold; Iain B Squire; Leong L Ng; Gerry P McCann
Journal:  Ther Adv Endocrinol Metab       Date:  2019-07-05       Impact factor: 3.565

4.  Atherosclerostic cardiovascular disease risk score: Are Indians underestimating the risk of cardiovascular disease?

Authors:  Ashish Kumar; Mariam Shariff
Journal:  Indian Heart J       Date:  2019-08-30

5.  Association of Diabetes Mellitus on Cardiac Remodeling, Quality of Life, and Clinical Outcomes in Heart Failure With Reduced and Preserved Ejection Fraction.

Authors:  Jonathan Yap; Wan Ting Tay; Tiew-Hwa Katherine Teng; Inder Anand; A Mark Richards; Lieng Hsi Ling; Michael R MacDonald; Chanchal Chandramouli; Jasper Tromp; Bambang B Siswanto; Michael Zile; John McMurray; Carolyn S P Lam
Journal:  J Am Heart Assoc       Date:  2019-08-21       Impact factor: 5.501

Review 6.  A Narrative Review on Sarcopenia in Type 2 Diabetes Mellitus: Prevalence and Associated Factors.

Authors:  Anna Izzo; Elena Massimino; Gabriele Riccardi; Giuseppe Della Pepa
Journal:  Nutrients       Date:  2021-01-09       Impact factor: 5.717

7.  Epicardial Adiposity in Relation to Metabolic Abnormality, Circulating Adipocyte FABP, and Preserved Ejection Fraction Heart Failure.

Authors:  Jiun-Lu Lin; Kuo-Tzu Sung; Yau-Huei Lai; Chih-Hsuan Yen; Chun-Ho Yun; Cheng-Huang Su; Jen-Yuan Kuo; Chia-Yuan Liu; Chen-Yen Chien; Ricardo C Cury; Hiram G Bezerra; Chung-Lieh Hung
Journal:  Diagnostics (Basel)       Date:  2021-02-26

8.  Multimorbidity in patients with heart failure from 11 Asian regions: A prospective cohort study using the ASIAN-HF registry.

Authors:  Jasper Tromp; Wan Ting Tay; Wouter Ouwerkerk; Tiew-Hwa Katherine Teng; Jonathan Yap; Michael R MacDonald; Kirsten Leineweber; John J V McMurray; Michael R Zile; Inder S Anand; A Mark Richards; Carolyn S P Lam
Journal:  PLoS Med       Date:  2018-03-27       Impact factor: 11.069

9.  South Indian Cuisine with Low Glycemic Index Ingredients Reduces Cardiovascular Risk Factors in Subjects with Type 2 Diabetes.

Authors:  Nivedita Pavithran; Harish Kumar; Arun Somasekharan Menon; Gopala Krishna Pillai; Karimassery Ramaiyer Sundaram; Omorogieva Ojo
Journal:  Int J Environ Res Public Health       Date:  2020-08-27       Impact factor: 3.390

10.  Clinical Phenotypes and Age-Related Differences in Presentation, Treatment, and Outcome of Heart Failure with Preserved Ejection Fraction: A Vietnamese Multicenter Research.

Authors:  Ngoc-Thanh-Van Nguyen; Diep Tuan Tran; Pham Le An; Sy Van Hoang; Hoai-An Nguyen; Hoa Ngoc Chau
Journal:  Cardiol Res Pract       Date:  2021-01-15       Impact factor: 1.866

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