Sujung Yoon1,2, Hanbyul Cho3, Jungyoon Kim1,2, Do-Wan Lee1, Geon Ha Kim1, Young Sun Hong4, Sohyeon Moon1,5, Shinwon Park1,2, Sunho Lee1,6, Suji Lee1,2, Sujin Bae7, Donald C Simonson8, In Kyoon Lyoo9,10,11. 1. Ewha Brain Institute, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, South Korea. 2. Department of Brain and Cognitive Sciences, Ewha Womans University, Seoul, South Korea. 3. The Brain Institute, University of Utah, Salt Lake City, UT, USA. 4. Division of Endocrinology & Metabolism, Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, South Korea. 5. Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, South Korea. 6. Interdisciplinary Program in Neurosciences, Seoul National University, Seoul, South Korea. 7. Department of Psychiatry, Chung Ang University Hospital, Seoul, South Korea. 8. Department of Internal Medicine, Brigham and Women's Hospital, Boston, MA, USA. 9. Ewha Brain Institute, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, South Korea. inkylyoo@ewha.ac.kr. 10. Department of Brain and Cognitive Sciences, Ewha Womans University, Seoul, South Korea. inkylyoo@ewha.ac.kr. 11. Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, South Korea. inkylyoo@ewha.ac.kr.
Abstract
AIMS/HYPOTHESIS: Overweight and obesity may significantly worsen glycaemic and metabolic control in type 2 diabetes. However, little is known about the effects of overweight and obesity on the brains of people with type 2 diabetes. Here, we investigate whether the presence of overweight or obesity influences the brain and cognitive functions during early stage type 2 diabetes. METHODS: This study attempted to uncouple the effects of overweight/obesity from those of type 2 diabetes on brain structures and cognition. Overweight/obese participants with type 2 diabetes had more severe and progressive abnormalities in their brain structures and cognition during early stage type 2 diabetes compared with participants with normal weight. Relationships between each of these measures and disease duration were also examined. RESULTS: Global mean cortical thickness was lower in the overweight/obese type 2 diabetes group than in the normal-weight type 2 diabetes group (z = -2.96, p for group effect = 0.003). A negative correlation was observed between disease duration and global mean white matter integrity (z = 2.42, p for interaction = 0.02) in the overweight/obese type 2 diabetes group, but not in the normal-weight type 2 diabetes group. Overweight/obese individuals with type 2 diabetes showed a decrease in psychomotor speed performance related to disease duration (z = -2.12, p for interaction = 0.03), while normal-weight participants did not. CONCLUSIONS/ INTERPRETATION: The current study attempted to uncouple the effects of overweight/obesity from those of type 2 diabetes on brain structures and cognition. Overweight/obese participants with type 2 diabetes had more severe and progressive abnormalities in brain structures and cognition during early stage type 2 diabetes compared with normal-weight participants.
AIMS/HYPOTHESIS: Overweight and obesity may significantly worsen glycaemic and metabolic control in type 2 diabetes. However, little is known about the effects of overweight and obesity on the brains of people with type 2 diabetes. Here, we investigate whether the presence of overweight or obesity influences the brain and cognitive functions during early stage type 2 diabetes. METHODS: This study attempted to uncouple the effects of overweight/obesity from those of type 2 diabetes on brain structures and cognition. Overweight/obeseparticipants with type 2 diabetes had more severe and progressive abnormalities in their brain structures and cognition during early stage type 2 diabetes compared with participants with normal weight. Relationships between each of these measures and disease duration were also examined. RESULTS: Global mean cortical thickness was lower in the overweight/obese type 2 diabetes group than in the normal-weight type 2 diabetes group (z = -2.96, p for group effect = 0.003). A negative correlation was observed between disease duration and global mean white matter integrity (z = 2.42, p for interaction = 0.02) in the overweight/obese type 2 diabetes group, but not in the normal-weight type 2 diabetes group. Overweight/obese individuals with type 2 diabetes showed a decrease in psychomotor speed performance related to disease duration (z = -2.12, p for interaction = 0.03), while normal-weight participants did not. CONCLUSIONS/ INTERPRETATION: The current study attempted to uncouple the effects of overweight/obesity from those of type 2 diabetes on brain structures and cognition. Overweight/obeseparticipants with type 2 diabetes had more severe and progressive abnormalities in brain structures and cognition during early stage type 2 diabetes compared with normal-weight participants.
Entities:
Keywords:
Cognitive function; Grey matter; Obesity; Overweight; Type 2 diabetes mellitus; White matter
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