Literature DB >> 28446818

Metabolic changes promote rejection of oncogenic cells.

Jonathan L Coloff1, Joan S Brugge1.   

Abstract

Dysfunctional cells are eliminated from epithelial monolayers by a process known as cell extrusion to maintain tissue homeostasis. Normal epithelial cells are now shown to induce the extrusion of oncogene-transformed cells by inducing metabolic changes in the oncogene-expressing cells through PDK4-mediated inhibition of PDH and mitochondrial metabolism.

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Mesh：

Year:  2017        PMID： 28446818     DOI： 10.1038/ncb3521

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  13 in total

1.  Characterization of the interface between normal and transformed epithelial cells.

Authors:  Catherine Hogan; Sophie Dupré-Crochet; Mark Norman; Mihoko Kajita; Carola Zimmermann; Andrew E Pelling; Eugenia Piddini; Luis Alberto Baena-López; Jean-Paul Vincent; Yoshifumi Itoh; Hiroshi Hosoya; Franck Pichaud; Yasuyuki Fujita
Journal:  Nat Cell Biol       Date:  2009-03-15       Impact factor: 28.824

2.  Filamin acts as a key regulator in epithelial defence against transformed cells.

Authors:  Mihoko Kajita; Kaoru Sugimura; Atsuko Ohoka; Jemima Burden; Hitomi Suganuma; Masaya Ikegawa; Takashi Shimada; Tetsuya Kitamura; Masanobu Shindoh; Susumu Ishikawa; Sayaka Yamamoto; Sayaka Saitoh; Yuta Yako; Ryosuke Takahashi; Takaharu Okajima; Junichi Kikuta; Yumiko Maijima; Masaru Ishii; Masazumi Tada; Yasuyuki Fujita
Journal:  Nat Commun       Date:  2014-07-31       Impact factor: 14.919

3.  Glucose oxidation modulates anoikis and tumor metastasis.

Authors:  Sushama Kamarajugadda; Lauren Stemboroski; Qingsong Cai; Nicholas E Simpson; Sushrusha Nayak; Ming Tan; Jianrong Lu
Journal:  Mol Cell Biol       Date:  2012-03-19       Impact factor: 4.272

4.  EPLIN is a crucial regulator for extrusion of RasV12-transformed cells.

Authors:  Atsuko Ohoka; Mihoko Kajita; Junichi Ikenouchi; Yuta Yako; Sho Kitamoto; Shunsuke Kon; Masaya Ikegawa; Takashi Shimada; Susumu Ishikawa; Yasuyuki Fujita
Journal:  J Cell Sci       Date:  2015-01-20       Impact factor: 5.285

5.  Autophagy in oncogenic K-Ras promotes basal extrusion of epithelial cells by degrading S1P.

Authors:  Gloria Slattum; Yapeng Gu; Roger Sabbadini; Jody Rosenblatt
Journal:  Curr Biol       Date:  2013-12-19       Impact factor: 10.834

6.  Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment.

Authors:  Zachary T Schafer; Alexandra R Grassian; Loling Song; Zhenyang Jiang; Zachary Gerhart-Hines; Hanna Y Irie; Sizhen Gao; Pere Puigserver; Joan S Brugge
Journal:  Nature       Date:  2009-08-19       Impact factor: 49.962

Review 7.  Cell Competition and Its Role in the Regulation of Cell Fitness from Development to Cancer.

Authors:  Aida Di Gregorio; Sarah Bowling; Tristan Argeo Rodriguez
Journal:  Dev Cell       Date:  2016-09-26       Impact factor: 12.270

8.  The tumor suppressor adenomatous polyposis coli controls the direction in which a cell extrudes from an epithelium.

Authors:  Thomas W Marshall; Isaac E Lloyd; Jean Marie Delalande; Inke Näthke; Jody Rosenblatt
Journal:  Mol Biol Cell       Date:  2011-09-07       Impact factor: 4.138

9.  THE METABOLISM OF TUMORS IN THE BODY.

Authors:  O Warburg; F Wind; E Negelein
Journal:  J Gen Physiol       Date:  1927-03-07       Impact factor: 4.086

10.  Reductive carboxylation supports redox homeostasis during anchorage-independent growth.

Authors:  Lei Jiang; Alexander A Shestov; Pamela Swain; Chendong Yang; Seth J Parker; Qiong A Wang; Lance S Terada; Nicholas D Adams; Michael T McCabe; Beth Pietrak; Stan Schmidt; Christian M Metallo; Brian P Dranka; Benjamin Schwartz; Ralph J DeBerardinis
Journal:  Nature       Date:  2016-04-06       Impact factor: 49.962
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  2 in total

Review 1.  Applications of vibrational tags in biological imaging by Raman microscopy.

Authors:  Zhilun Zhao; Yihui Shen; Fanghao Hu; Wei Min
Journal:  Analyst       Date:  2017-10-23       Impact factor: 4.616

2.  A single-cell atlas of the healthy breast tissues reveals clinically relevant clusters of breast epithelial cells.

Authors:  Poornima Bhat-Nakshatri; Hongyu Gao; Liu Sheng; Patrick C McGuire; Xiaoling Xuei; Jun Wan; Yunlong Liu; Sandra K Althouse; Austyn Colter; George Sandusky; Anna Maria Storniolo; Harikrishna Nakshatri
Journal:  Cell Rep Med       Date:  2021-03-16
  2 in total

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