Literature DB >> 28446671

Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen: Replicating and Shielding Viral DNA during Viral Persistence.

Magdalena Weidner-Glunde1, Giuseppe Mariggiò1, Thomas F Schulz2.   

Abstract

Kaposi's sarcoma herpesvirus (KSHV) establishes lifelong latency. The viral latency-associated nuclear antigen (LANA) promotes viral persistence by tethering the viral genome to cellular chromosomes and by participating in latent DNA replication. Recently, the structure of the LANA C-terminal DNA binding domain was solved and new cytoplasmic variants of LANA were discovered. We discuss how these findings contribute to our current view of LANA structure and assembly and of its role during viral persistence.
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  Kaposi's sarcoma-associated herpesvirus; LANA speckles; cytoplasmic DNA sensors; cytoplasmic variants; structure; virus persistence

Mesh：

Substances：

Year:  2017        PMID： 28446671      PMCID： PMC5487577          DOI： 10.1128/JVI.01083-16

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  113 in total

1.  Transcripts encoding K12, v-FLIP, v-cyclin, and the microRNA cluster of Kaposi's sarcoma-associated herpesvirus originate from a common promoter.

Authors:  Michael Pearce; Satoko Matsumura; Angus C Wilson
Journal:  J Virol       Date:  2005-11       Impact factor: 5.103

2.  Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8).

Authors:  J J Russo; R A Bohenzky; M C Chien; J Chen; M Yan; D Maddalena; J P Parry; D Peruzzi; I S Edelman; Y Chang; P S Moore
Journal:  Proc Natl Acad Sci U S A       Date:  1996-12-10       Impact factor: 11.205

3.  The latency-associated nuclear antigen tethers the Kaposi's sarcoma-associated herpesvirus genome to host chromosomes in body cavity-based lymphoma cells.

Authors:  M A Cotter; E S Robertson
Journal:  Virology       Date:  1999-11-25       Impact factor: 3.616

4.  Activation of alternative NF-kappa B pathway by human herpes virus 8-encoded Fas-associated death domain-like IL-1 beta-converting enzyme inhibitory protein (vFLIP).

Authors:  Hittu Matta; Preet M Chaudhary
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-09       Impact factor: 11.205

5.  Influence of ND10 components on epigenetic determinants of early KSHV latency establishment.

Authors:  Thomas Günther; Sabrina Schreiner; Thomas Dobner; Uwe Tessmer; Adam Grundhoff
Journal:  PLoS Pathog       Date:  2014-07-17       Impact factor: 6.823

6.  Kaposi's sarcoma-associated herpesvirus LANA recruits the DNA polymerase clamp loader to mediate efficient replication and virus persistence.

Authors:  Qiming Sun; Toshiki Tsurimoto; Franceline Juillard; Lin Li; Shijun Li; Erika De León Vázquez; She Chen; Kenneth Kaye
Journal:  Proc Natl Acad Sci U S A       Date:  2014-07-28       Impact factor: 11.205

7.  Conservation of complex nuclear localization signals utilizing classical and non-classical nuclear import pathways in LANA homologs of KSHV and RFHV.

Authors:  Lidia Cherezova; Kellie L Burnside; Timothy M Rose
Journal:  PLoS One       Date:  2011-04-29       Impact factor: 3.240

8.  The RBP-Jκ binding sites within the RTA promoter regulate KSHV latent infection and cell proliferation.

Authors:  Jie Lu; Subhash C Verma; Qiliang Cai; Abhik Saha; Richard Kuo Dzeng; Erle S Robertson
Journal:  PLoS Pathog       Date:  2012-01-12       Impact factor: 6.823

9.  A structural basis for BRD2/4-mediated host chromatin interaction and oligomer assembly of Kaposi sarcoma-associated herpesvirus and murine gammaherpesvirus LANA proteins.

Authors:  Jan Hellert; Magdalena Weidner-Glunde; Joern Krausze; Ulrike Richter; Heiko Adler; Roman Fedorov; Marcel Pietrek; Jessica Rückert; Christiane Ritter; Thomas F Schulz; Thorsten Lührs
Journal:  PLoS Pathog       Date:  2013-10-17       Impact factor: 6.823

Review 10.  Cell Cycle Regulatory Functions of the KSHV Oncoprotein LANA.

Authors:  Fang Wei; Jin Gan; Chong Wang; Caixia Zhu; Qiliang Cai
Journal:  Front Microbiol       Date:  2016-03-30       Impact factor: 5.640
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  13 in total

Review 1.  The Transcriptome of Latent Human Cytomegalovirus.

Authors:  Michal Schwartz; Noam Stern-Ginossar
Journal:  J Virol       Date:  2019-05-15       Impact factor: 5.103

2.  Cryo-EM Structure and Functional Studies of EBNA1 Binding to the Family of Repeats and Dyad Symmetry Elements of Epstein-Barr Virus oriP.

Authors:  Yang Mei; Troy E Messick; Jayaraju Dheekollu; Hee Jong Kim; Sudheer Molugu; Leonardo Josué Castro Muñoz; Vera Moiskeenkova-Bell; Kenji Murakami; Paul M Lieberman
Journal:  J Virol       Date:  2022-08-29       Impact factor: 6.549

3.  Superresolution microscopy reveals structural mechanisms driving the nanoarchitecture of a viral chromatin tether.

Authors:  Margaret J Grant; Matthew S Loftus; Aiola P Stoja; Dean H Kedes; M Mitchell Smith
Journal:  Proc Natl Acad Sci U S A       Date:  2018-04-02       Impact factor: 11.205

Review 4.  Control of Viral Latency by Episome Maintenance Proteins.

Authors:  Alessandra De Leo; Abram Calderon; Paul M Lieberman
Journal:  Trends Microbiol       Date:  2019-10-14       Impact factor: 17.079

Review 5.  Coevolution pays off: Herpesviruses have the license to escape the DNA sensing pathway.

Authors:  Markus Stempel; Baca Chan; Melanie M Brinkmann
Journal:  Med Microbiol Immunol       Date:  2019-02-25       Impact factor: 4.148

6.  The Kaposi's sarcoma-associated herpesvirus (KSHV) non-structural membrane protein K15 is required for viral lytic replication and may represent a therapeutic target.

Authors:  Bizunesh Abere; Tamrat M Mamo; Silke Hartmann; Naira Samarina; Elias Hage; Jessica Rückert; Sven-Kevin Hotop; Guntram Büsche; Thomas F Schulz
Journal:  PLoS Pathog       Date:  2017-09-22       Impact factor: 6.823

7.  NDRG1 facilitates the replication and persistence of Kaposi's sarcoma-associated herpesvirus by interacting with the DNA polymerase clamp PCNA.

Authors:  Fang Zhang; Deguang Liang; Xiaoxi Lin; Zhe Zou; Rui Sun; Xing Wang; Xiaozhen Liang; Kenneth M Kaye; Ke Lan
Journal:  PLoS Pathog       Date:  2019-02-27       Impact factor: 6.823

8.  Human Immunodeficiency Virus-Associated Exosomes Promote Kaposi's Sarcoma-Associated Herpesvirus Infection via the Epidermal Growth Factor Receptor.

Authors:  Lechuang Chen; Zhimin Feng; Guoxiang Yuan; Corey C Emerson; Phoebe L Stewart; Fengchun Ye; Ge Jin
Journal:  J Virol       Date:  2020-04-16       Impact factor: 5.103

9.  LANA oligomeric architecture is essential for KSHV nuclear body formation and viral genome maintenance during latency.

Authors:  Alessandra De Leo; Zhong Deng; Olga Vladimirova; Horng-Shen Chen; Jayaraju Dheekollu; Abram Calderon; Kenneth A Myers; James Hayden; Frederick Keeney; Benedikt B Kaufer; Yan Yuan; Erle Robertson; Paul M Lieberman
Journal:  PLoS Pathog       Date:  2019-01-25       Impact factor: 6.823

10.  Identification of Mubritinib (TAK 165) as an inhibitor of KSHV driven primary effusion lymphoma via disruption of mitochondrial OXPHOS metabolism.

Authors:  Abram Calderon; Samantha S Soldan; Alessandra De Leo; Zhong Deng; Drew M Frase; Emma M Anderson; Yue Zhang; Olga Vladimirova; Fang Lu; Jessica C Leung; Maureen E Murphy; Paul M Lieberman
Journal:  Oncotarget       Date:  2020-11-17
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