| Literature DB >> 28446663 |
Hilary E Faust1,2, Jeffrey A Golden2, Raja Rajalingam2, Angelia S Wang2, Gary Green2, Steven R Hays2, Jasleen Kukreja2, Jonathan P Singer2, Paul J Wolters2, John R Greenland2,3.
Abstract
Telomere length (TL) decreases with cellular ageing and biological stressors. As advanced donor and recipient ages are risk factors for chronic lung allograft dysfunction (CLAD), we hypothesised that decreased age-adjusted donor TL would predict earlier onset of CLAD. Shorter donor TL was associated with increased risk of CLAD or death (HR 1.26 per 1 kb TL decrease, 95% CI 1.03 to 1.54), particularly for young donors. Recipient TL was associated with cytopenias but not CLAD. Shorter TL was also seen in airway epithelium for subjects progressing to CLAD (p=0.02). Allograft TL may contribute to CLAD pathogenesis and facilitate risk stratification. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.Entities:
Keywords: Lung Transplantation
Mesh：
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Year: 2017 PMID： 28446663 PMCID： PMC6550329 DOI： 10.1136/thoraxjnl-2016-209897
Source DB: PubMed Journal: Thorax ISSN： 0040-6376 Impact factor: 9.139