Graeme D Jackson1, Mangor Pedersen2, A Simon Harvey2. 1. From The Florey Institute of Neuroscience and Mental Health (G.D.J., M.P.), The University of Melbourne; Department of Neurology (G.D.J.), Austin Health; and Department of Neurology (A.S.H.), Royal Children's Hospital, Melbourne, Australia. g.jackson@brain.org.au. 2. From The Florey Institute of Neuroscience and Mental Health (G.D.J., M.P.), The University of Melbourne; Department of Neurology (G.D.J.), Austin Health; and Department of Neurology (A.S.H.), Royal Children's Hospital, Melbourne, Australia.
Abstract
OBJECTIVE: To present a case that demonstrates that seizures and interictal disturbances can be driven by a small area of functionally abnormal cortex. METHODS: Two novel functional MRI network analysis methods were used to supplement conventional seizure and lesion localization methods: (1) regional homogeneity to quantify local connectivity, or synchrony, with a resolution of less than 1 cm3 of cortex; and (2) small-worldness to combine information about whole brain network segregation and integration. RESULTS: After a small corticectomy in the dominant supramarginal gyrus (13 × 7 × 6 mm) limited to the area of abnormal local connectivity, and smaller than the PET and SPECT abnormalities, the patient has been seizure-free for 3 years with no language deficit. Whole brain network characteristics normalized (small-worldness) to that of healthy controls. CONCLUSIONS: This case demonstrates that small areas of cortex may be highly epileptogenic, drive intractable epilepsy, and disrupt large-scale networks likely to be involved in core cognitive functions.
OBJECTIVE: To present a case that demonstrates that seizures and interictal disturbances can be driven by a small area of functionally abnormal cortex. METHODS: Two novel functional MRI network analysis methods were used to supplement conventional seizure and lesion localization methods: (1) regional homogeneity to quantify local connectivity, or synchrony, with a resolution of less than 1 cm3 of cortex; and (2) small-worldness to combine information about whole brain network segregation and integration. RESULTS: After a small corticectomy in the dominant supramarginal gyrus (13 × 7 × 6 mm) limited to the area of abnormal local connectivity, and smaller than the PET and SPECT abnormalities, the patient has been seizure-free for 3 years with no language deficit. Whole brain network characteristics normalized (small-worldness) to that of healthy controls. CONCLUSIONS: This case demonstrates that small areas of cortex may be highly epileptogenic, drive intractable epilepsy, and disrupt large-scale networks likely to be involved in core cognitive functions.
Authors: Amir Omidvarnia; Mangor Pedersen; David N Vaughan; Jennifer M Walz; David F Abbott; Andrew Zalesky; Graeme D Jackson Journal: Hum Brain Mapp Date: 2017-07-24 Impact factor: 5.038
Authors: Shahin Tavakol; Jessica Royer; Alexander J Lowe; Leonardo Bonilha; Joseph I Tracy; Graeme D Jackson; John S Duncan; Andrea Bernasconi; Neda Bernasconi; Boris C Bernhardt Journal: Epilepsia Date: 2019-03-19 Impact factor: 5.864
Authors: Mangor Pedersen; Amir Omidvarnia; Evan K Curwood; Jennifer M Walz; Genevieve Rayner; Graeme D Jackson Journal: Neuroimage Clin Date: 2017-04-11 Impact factor: 4.881
Authors: Pavel Říha; Irena Doležalová; Radek Mareček; Martin Lamoš; Michaela Bartoňová; Martin Kojan; Michal Mikl; Martin Gajdoš; Lubomír Vojtíšek; Marek Bartoň; Ondřej Strýček; Martin Pail; Milan Brázdil; Ivan Rektor Journal: Sci Rep Date: 2022-09-07 Impact factor: 4.996