Literature DB >> 28446061

Signaling by Antibodies: Recent Progress.

Stylianos Bournazos1, Taia T Wang1, Rony Dahan1, Jad Maamary1, Jeffrey V Ravetch1.   

Abstract

IgG antibodies mediate a diversity of immune functions by coupling of antigen specificity through the Fab domain to signal transduction via Fc-Fc receptor interactions. Indeed, balanced IgG signaling through type I and type II Fc receptors is required for the control of proinflammatory, anti-inflammatory, and immunomodulatory processes. In this review, we discuss the mechanisms that govern IgG-Fc receptor interactions, highlighting the diversity of Fc receptor-mediated effector functions that regulate immunity and inflammation as well as determine susceptibility to infection and autoimmunity and responsiveness to antibody-based therapeutics and vaccines.

Entities:  

Keywords:  Fc receptors; IgG; effector function; immunity; immunomodulation; inflammation

Mesh：

Substances：

Year:  2017        PMID： 28446061      PMCID： PMC5613280          DOI： 10.1146/annurev-immunol-051116-052433

Source DB:  PubMed          Journal:  Annu Rev Immunol        ISSN： 0732-0582            Impact factor:   28.527


  148 in total

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Journal:  Blood       Date:  2002-02-01       Impact factor: 22.113

3.  Recognition of influenza A virus nucleoprotein by an H-2-restricted cytotoxic T-cell clone.

Authors:  A R Townsend; J J Skehel; P M Taylor; P Palese
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4.  Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells.

Authors:  Mark J Selby; John J Engelhardt; Michael Quigley; Karla A Henning; Timothy Chen; Mohan Srinivasan; Alan J Korman
Journal:  Cancer Immunol Res       Date:  2013-04-07       Impact factor: 11.151

5.  GA201 (RG7160): a novel, humanized, glycoengineered anti-EGFR antibody with enhanced ADCC and superior in vivo efficacy compared with cetuximab.

Authors:  Christian A Gerdes; Valeria Gonzalez Nicolini; Sylvia Herter; Erwin van Puijenbroek; Sabine Lang; Michaela Roemmele; Ekkehard Moessner; Olivier Freytag; Thomas Friess; Carola H Ries; Birgit Bossenmaier; Hans Joachim Mueller; Pablo Umaña
Journal:  Clin Cancer Res       Date:  2012-12-03       Impact factor: 12.531

6.  Primary human splenic macrophages, but not T or B cells, are the principal target cells for dengue virus infection in vitro.

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Review 7.  The coordination of signaling during Fc receptor-mediated phagocytosis.

Authors:  Joel A Swanson; Adam D Hoppe
Journal:  J Leukoc Biol       Date:  2004-10-05       Impact factor: 4.962

8.  General mechanism for modulating immunoglobulin effector function.

Authors:  Peter Sondermann; Andrew Pincetic; Jad Maamary; Katja Lammens; Jeffrey V Ravetch
Journal:  Proc Natl Acad Sci U S A       Date:  2013-05-22       Impact factor: 11.205

9.  Nivolumab plus ipilimumab in advanced melanoma.

Authors:  Jedd D Wolchok; Harriet Kluger; Margaret K Callahan; Michael A Postow; Naiyer A Rizvi; Alexander M Lesokhin; Neil H Segal; Charlotte E Ariyan; Ruth-Ann Gordon; Kathleen Reed; Matthew M Burke; Anne Caldwell; Stephanie A Kronenberg; Blessing U Agunwamba; Xiaoling Zhang; Israel Lowy; Hector David Inzunza; William Feely; Christine E Horak; Quan Hong; Alan J Korman; Jon M Wigginton; Ashok Gupta; Mario Sznol
Journal:  N Engl J Med       Date:  2013-06-02       Impact factor: 91.245

10.  FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity.

Authors:  Manuela Fanciulli; Penny J Norsworthy; Enrico Petretto; Rong Dong; Lorraine Harper; Lavanya Kamesh; Joanne M Heward; Stephen C L Gough; Adam de Smith; Alexandra I F Blakemore; Philippe Froguel; Catherine J Owen; Simon H S Pearce; Luis Teixeira; Loic Guillevin; Deborah S Cunninghame Graham; Charles D Pusey; H Terence Cook; Timothy J Vyse; Timothy J Aitman
Journal:  Nat Genet       Date:  2007-05-21       Impact factor: 38.330
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  69 in total

1.  Immunotherapy and Hyperprogression: Unwanted Outcomes, Unclear Mechanism.

Authors:  David A Knorr; Jeffrey V Ravetch
Journal:  Clin Cancer Res       Date:  2018-11-05       Impact factor: 12.531

2.  Transcytosis route mediates rapid delivery of intact antibodies to draining lymph nodes.

Authors:  Laura Kähäri; Ruth Fair-Mäkelä; Kaisa Auvinen; Pia Rantakari; Sirpa Jalkanen; Johanna Ivaska; Marko Salmi
Journal:  J Clin Invest       Date:  2019-06-24       Impact factor: 14.808

3.  Differential requirements for FcγR engagement by protective antibodies against Ebola virus.

Authors:  Stylianos Bournazos; David J DiLillo; Arthur J Goff; Pamela J Glass; Jeffrey V Ravetch
Journal:  Proc Natl Acad Sci U S A       Date:  2019-09-04       Impact factor: 11.205

Review 4.  Functional diversification of IgGs through Fc glycosylation.

Authors:  Taia T Wang; Jeffrey V Ravetch
Journal:  J Clin Invest       Date:  2019-09-03       Impact factor: 14.808

5.  Development and characterization of CD54-targeted immunoPET imaging in solid tumors.

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6.  Increasing the breadth and potency of response to the seasonal influenza virus vaccine by immune complex immunization.

Authors:  Jad Maamary; Taia T Wang; Gene S Tan; Peter Palese; Jeffrey V Ravetch
Journal:  Proc Natl Acad Sci U S A       Date:  2017-09-05       Impact factor: 11.205

7.  IGHG, IGKC, and FCGR genes and endogenous antibody responses to GARP in patients with breast cancer and matched controls.

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8.  Opsonization-Enhanced Antigen Presentation by MR1 Activates Rapid Polyfunctional MAIT Cell Responses Acting as an Effector Arm of Humoral Antibacterial Immunity.

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Journal:  J Immunol       Date:  2020-05-20       Impact factor: 5.422

Review 9.  Immunological responses to influenza vaccination: lessons for improving vaccine efficacy.

Authors:  Taia T Wang; Stylianos Bournazos; Jeffrey V Ravetch
Journal:  Curr Opin Immunol       Date:  2018-05-10       Impact factor: 7.486

Review 10.  Tolerogenic properties of the Fc portion of IgG and its relevance to the treatment and management of hemophilia

Authors:  Richard S Blumberg; David Lillicrap
Journal:  Blood       Date:  2018-03-27       Impact factor: 22.113
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