Josafá Gonçalves Barreto1, Marco Andrey Cipriani Frade2, Fred Bernardes Filho2, Moises Batista da Silva3, John Stewart Spencer4, Claudio Guedes Salgado3. 1. Spatial Epidemiology Laboratory, Federal University of Pará, Campus Castanhal, Avenida dos Universitários, s/n, Bairro Jaderlândia Castanhal, Pará, CEP: 68746-360, Brazil. jbarreto@ufpa.br. 2. Divison of Dermatology of Internal Medicine, Department of Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes, 3900, Monte Alegre, Ribeirão Preto, São Paulo, CEP: 14.049.900, Brazil. 3. Dermato-Immunology Laboratory, Federal University of Pará, Av. João Paulo II, 113 - Bairro Dom Aristides, Marituba, Pará, CEP: 67200-000, Brazil. 4. Department of Microbiology, Immunology and Pathology, Colorado State University, 1682 Campus Delivery, Fort Collins, CO, 80523-1682, USA.
Abstract
PURPOSE OF REVIEW: This manuscript aims to review the cutting-edge developments regarding to the diagnosis, management, and prevention of leprosy in children. RECENT FINDINGS: Leprosy transmission still occurs continuously in some endemic areas in the world. Leprosy in children below 15 years old is a robust indicator of active source of infection in the community where they live. A special focus on children to reduce disabilities and reduce transmission is one of the core areas of interventions of the global leprosy strategy 2016-2020. Ongoing research is trying to develop better diagnostic tests and to advance chemoprophylaxis and immunoprophylaxis approaches. Early diagnosis in children can be hard because of the wide range of clinical aspects of the skin lesions and mainly due to the difficulty of performing the clinical peripheral nerve evaluation. We must maintain leprosy expertise and improve the health professionals training for leprosy diagnosis, since we still have a long journey to reach leprosy elimination.
PURPOSE OF REVIEW: This manuscript aims to review the cutting-edge developments regarding to the diagnosis, management, and prevention of leprosy in children. RECENT FINDINGS: Leprosy transmission still occurs continuously in some endemic areas in the world. Leprosy in children below 15 years old is a robust indicator of active source of infection in the community where they live. A special focus on children to reduce disabilities and reduce transmission is one of the core areas of interventions of the global leprosy strategy 2016-2020. Ongoing research is trying to develop better diagnostic tests and to advance chemoprophylaxis and immunoprophylaxis approaches. Early diagnosis in children can be hard because of the wide range of clinical aspects of the skin lesions and mainly due to the difficulty of performing the clinical peripheral nerve evaluation. We must maintain leprosy expertise and improve the health professionals training for leprosy diagnosis, since we still have a long journey to reach leprosy elimination.
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Authors: J Hessel M van Dijk; Anouk van Hooij; L Melanie Groot; Jolijn Geboers; Rosita Moretti; Els Verhard-Seymonsbergen; Danielle de Jong; Gijs A van der Marel; Paul L A M Corstjens; Jeroen D C Codée; Annemieke Geluk Journal: Chembiochem Date: 2021-02-10 Impact factor: 3.164