Literature DB >> 2844416

A novel role for cAMP in the control of the activity of the E. coli chromosome replication initiator protein, DnaA.

P Hughes1, A Landoulsi, M Kohiyama.   

Abstract

DnaA protein interacts with cAMP with a KD of 1 microM. This interaction stimulates DnaA protein binding to the chromosome replication origin (oriC) and the mioC promoter region, protects DnaA protein from thermal inactivation, releases ADP but not ATP bound to DnaA protein, and restores normal DNA replication activity and ATPase activity in inactive ADP-DnaA protein preparations. A model is proposed in which cellular cAMP levels govern the replication activity of DnaA protein by promoting the recycling of the inactive ADP-DnaA protein form into the active ATP form.

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Year:  1988        PMID： 2844416     DOI： 10.1016/0092-8674(88)90057-8

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  19 in total

1.  Cyclic AMP and acyl homoserine lactones increase the cultivation efficiency of heterotrophic bacteria from the central Baltic Sea.

Authors:  Alke Bruns; Heribert Cypionka; Jörg Overmann
Journal:  Appl Environ Microbiol       Date:  2002-08       Impact factor: 4.792

Review 2.  Cyclic AMP in prokaryotes.

Authors:  J L Botsford; J G Harman
Journal:  Microbiol Rev       Date:  1992-03

3.  In vitro roles of Escherichia coli DnaJ and DnaK heat shock proteins in the replication of oriC plasmids.

Authors:  A Malki; P Hughes; M Kohiyama
Journal:  Mol Gen Genet       Date:  1991-03

4.  DnaA dependent replication of plasmid R1 occurs in the presence of point mutations that disrupt the dnaA box of oriR.

Authors:  S Ortega-Jiménez; R Giraldo-Suárez; M E Fernández-Tresguerres; A Berzal-Herranz; R Díaz-Orejas
Journal:  Nucleic Acids Res       Date:  1992-05-25       Impact factor: 16.971

5.  EshA accentuates ppGpp accumulation and is conditionally required for antibiotic production in Streptomyces coelicolor A3(2).

Authors:  Natsumi Saito; Jun Xu; Takeshi Hosaka; Susumu Okamoto; Hiroyuki Aoki; Mervyn J Bibb; Kozo Ochi
Journal:  J Bacteriol       Date:  2006-07       Impact factor: 3.490

6.  Identification and characterization of a developmentally regulated protein, EshA, required for sporogenic hyphal branches in Streptomyces griseus.

Authors:  J Kwak; L A McCue; K Trczianka; K E Kendrick
Journal:  J Bacteriol       Date:  2001-05       Impact factor: 3.490

7.  Inhibition of DNA synthesis at the hemimethylated pBR322 origin of replication by a cell membrane fraction.

Authors:  A Malki; R Kern; M Kohiyama; P Hughes
Journal:  Nucleic Acids Res       Date:  1992-01-11       Impact factor: 16.971

8.  Initiation of chromosomal DNA replication which is stimulated without oversupply of DnaA protein in Escherichia coli.

Authors:  T Katayama; T Nagata
Journal:  Mol Gen Genet       Date:  1991-05

Review 9.  Control of cyclic chromosome replication in Escherichia coli.

Authors:  H Bremer; G Churchward
Journal:  Microbiol Rev       Date:  1991-09

10.  dam methylation and the initiation of DNA replication on oriC plasmids.

Authors:  A Landoulsi; P Hughes; R Kern; M Kohiyama
Journal:  Mol Gen Genet       Date:  1989-04
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