Maria Alice Muniz Domingos1, Alessandra Carvalho Goulart2, Paulo Andrade Lotufo3, Isabela Judith Martins Benseñor4, Silvia Maria de Oliveira Titan5. 1. MD, PhD. Nephrologist, Renal Division, Department of Clinical Medicine, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo (SP), Brazil. 2. MD, PhD. Clinical Epidemiologist and Researcher, Clinical Research Center, University Hospital, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo (SP), Brazil. 3. MD, PhD. Full Professor, Clinical Research Center, University Hospital, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo (SP), Brazil. 4. MD, PhD. Assistant Professor, Clinical Research Center, University Hospital, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo (SP), Brazil. 5. MD, PhD. Research Investigator, Renal Division, Department of Clinical Medicine, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo (SP), Brazil.
Abstract
CONTEXT AND OBJECTIVE: : Chronic kidney disease (CKD) has become an important public health issue. The socioeconomic burden of renal replacement therapy (RRT) is very high, as is CKD-related cardiovascular mortality and morbidity. Preventive and therapeutic measures only have modest impact and more research is needed. Few cohort studies have been conducted on populations with CKD. Our aim was to establish a cohort that would include more advanced forms of CKD (stages 3 and 4). Data collection was focused on renal and cardiovascular parameters. DESIGN AND SETTING: : Prospective cohort study; São Paulo, Brazil. METHODS: : Recruitment took place in Hospital das Clínicas, São Paulo, from March 2012 to December 2013. Data relating to medical history, food-frequency questionnaire, anthropometry, laboratory work-up, calcium score, echocardiography, carotid intimal-medial thickness, pulse-wave velocity, retinography and heart rate variability were collected. A biobank including serum, plasma, post-oral glucose tolerance test serum and plasma, urine (morning and 24-hour urine) and DNA was established. RESULTS: : 454 participants (60% men and 50% diabetics) of mean age 68 years were enrolled. Their mean estimated glomerular filtration rate-CKD Epidemiology Collaboration was 38 ml/min/1.73 m2. Follow-up is ongoing and the main outcomes are the start of RRT, cardiovascular events and death. CONCLUSIONS: : The PROGREDIR cohort is a promising prospective study that will allow better understanding of CKD determinants and validation of candidate biomarkers for the risks of CKD progression and mortality.
CONTEXT AND OBJECTIVE: : Chronic kidney disease (CKD) has become an important public health issue. The socioeconomic burden of renal replacement therapy (RRT) is very high, as is CKD-related cardiovascular mortality and morbidity. Preventive and therapeutic measures only have modest impact and more research is needed. Few cohort studies have been conducted on populations with CKD. Our aim was to establish a cohort that would include more advanced forms of CKD (stages 3 and 4). Data collection was focused on renal and cardiovascular parameters. DESIGN AND SETTING: : Prospective cohort study; São Paulo, Brazil. METHODS: : Recruitment took place in Hospital das Clínicas, São Paulo, from March 2012 to December 2013. Data relating to medical history, food-frequency questionnaire, anthropometry, laboratory work-up, calcium score, echocardiography, carotid intimal-medial thickness, pulse-wave velocity, retinography and heart rate variability were collected. A biobank including serum, plasma, post-oral glucose tolerance test serum and plasma, urine (morning and 24-hour urine) and DNA was established. RESULTS: : 454 participants (60% men and 50% diabetics) of mean age 68 years were enrolled. Their mean estimated glomerular filtration rate-CKD Epidemiology Collaboration was 38 ml/min/1.73 m2. Follow-up is ongoing and the main outcomes are the start of RRT, cardiovascular events and death. CONCLUSIONS: : The PROGREDIR cohort is a promising prospective study that will allow better understanding of CKD determinants and validation of candidate biomarkers for the risks of CKD progression and mortality.
Authors: Alisson Diego Machado; Luz Marina Gómez; Dirce Maria Lobo Marchioni; Fernanda Silva Nogueira Dos Anjos; Maria Del Carmen Bisi Molina; Paulo Andrade Lotufo; Isabela Judith Martins Benseñor; Silvia Maria de Oliveira Titan Journal: Nutrients Date: 2018-03-19 Impact factor: 5.717
Authors: Silvia M Titan; Gabriela Venturini; Kallyandra Padilha; Alessandra C Goulart; Paulo A Lotufo; Isabela J Bensenor; Jose E Krieger; Ravi I Thadhani; Eugene P Rhee; Alexandre C Pereira Journal: PLoS One Date: 2019-03-18 Impact factor: 3.240
Authors: Wesley de Souza; Luiz Carlos de Abreu; Leonardo Gomes da Silva; Italla Maria Pinheiro Bezerra Journal: PLoS One Date: 2019-11-07 Impact factor: 3.240