BACKGROUND: Obstructive lung disorder (OLD) is known to be associated with cardiovascular disease. However, the impact of restrictive lung disorder (RLD) on cardiovascular mortality has not been fully investigated in the apparently healthy general population. OBJECTIVES: To clarify whether RLD is associated with cardiovascular mortality in the general population. METHODS AND RESULTS: This community-based cohort study included 3247 subjects who participated in an annual health check in Takahata. We performed spirometry in registered subjects and found that 194 (6%) had RLD, 262 (8%) had OLD, and 73 (2%) had RLD and OLD (Mixed). During a 10-year follow-up, there were 210 deaths, including 57 cardiovascular deaths. Cardiovascular mortality of subjects with RLD was significantly higher than that of subjects with normal lung function. Although the subjects with RLD were younger, comprised fewer smokers, and were more likely to be female than those with OLD, cardiovascular mortality of subjects with RLD was comparable to that of subjects with OLD. Subjects with RLD had a higher prevalence of atrial fibrillation (AF) than those with OLD, and the prevalence of AF was increased with advanced severity of RLD. Multivariate Cox proportional hazard analysis revealed that RLD was an independent predictor of cardiovascular death (hazard ratio 2.61, 95% confidence interval, 1.22-5.21) after adjustment for confounders, but OLD was not. The net reclassification improvement and integrated discrimination improvement were significantly increased by the addition of RLD to conventional cardiovascular risk factors. CONCLUSION: The presence of RLD was associated with cardiovascular mortality in the general population.
BACKGROUND:Obstructive lung disorder (OLD) is known to be associated with cardiovascular disease. However, the impact of restrictive lung disorder (RLD) on cardiovascular mortality has not been fully investigated in the apparently healthy general population. OBJECTIVES: To clarify whether RLD is associated with cardiovascular mortality in the general population. METHODS AND RESULTS: This community-based cohort study included 3247 subjects who participated in an annual health check in Takahata. We performed spirometry in registered subjects and found that 194 (6%) had RLD, 262 (8%) had OLD, and 73 (2%) had RLD and OLD (Mixed). During a 10-year follow-up, there were 210 deaths, including 57 cardiovascular deaths. Cardiovascular mortality of subjects with RLD was significantly higher than that of subjects with normal lung function. Although the subjects with RLD were younger, comprised fewer smokers, and were more likely to be female than those with OLD, cardiovascular mortality of subjects with RLD was comparable to that of subjects with OLD. Subjects with RLD had a higher prevalence of atrial fibrillation (AF) than those with OLD, and the prevalence of AF was increased with advanced severity of RLD. Multivariate Cox proportional hazard analysis revealed that RLD was an independent predictor of cardiovascular death (hazard ratio 2.61, 95% confidence interval, 1.22-5.21) after adjustment for confounders, but OLD was not. The net reclassification improvement and integrated discrimination improvement were significantly increased by the addition of RLD to conventional cardiovascular risk factors. CONCLUSION: The presence of RLD was associated with cardiovascular mortality in the general population.
Authors: Emily S Wan; John E Hokanson; Elizabeth A Regan; Kendra A Young; Barry J Make; Dawn L DeMeo; Stefanie E Mason; Raul San Jose Estepar; James D Crapo; Edwin K Silverman Journal: Chest Date: 2021-09-27 Impact factor: 9.410
Authors: Emily S Wan; Spyridon Fortis; Elizabeth A Regan; John Hokanson; MeiLan K Han; Richard Casaburi; Barry J Make; James D Crapo; Dawn L DeMeo; Edwin K Silverman Journal: Am J Respir Crit Care Med Date: 2018-12-01 Impact factor: 30.528
Authors: Gang Wang; Jenny Hallberg; Dimitrios Charalampopoulos; Maribel Casas Sanahuja; Robab Breyer-Kohansal; Arnulf Langhammer; Raquel Granell; Judith M Vonk; Annemiek Mian; Núria Olvera; Lisbeth Mølgaard Laustsen; Eva Rönmark; Alicia Abellan; Alvar Agusti; Syed Hasan Arshad; Anna Bergström; H Marike Boezen; Marie-Kathrin Breyer; Otto Burghuber; Anneli Clea Bolund; Adnan Custovic; Graham Devereux; Gavin C Donaldson; Liesbeth Duijts; Ana Esplugues; Rosa Faner; Ferran Ballester; Judith Garcia-Aymerich; Ulrike Gehring; Sadia Haider; Sylvia Hartl; Helena Backman; John W Holloway; Gerard H Koppelman; Aitana Lertxundi; Turid Lingaas Holmen; Lesley Lowe; Sara M Mensink-Bout; Clare S Murray; Graham Roberts; Linnea Hedman; Vivi Schlünssen; Torben Sigsgaard; Angela Simpson; Jordi Sunyer; Maties Torrent; Stephen Turner; Maarten Van den Berge; Roel C H Vermeulen; Sigrid Anna Aalberg Vikjord; Jadwiga A Wedzicha; Anke H Maitland van der Zee; Erik Melén Journal: ERJ Open Res Date: 2021-12-06