Enric Sánchez1, Juan Antonio Baena-Fustegueras2, María Cruz de la Fuente2, Liliana Gutiérrez1, Marta Bueno1, Susana Ros2, Albert Lecube3. 1. Servicio de Endocrinología y Nutrición, Hospital Universitario Arnau de Vilanova, Institut de Recerca Biomèdica (IRB) de Lleida, Universitat de Lleida, Lleida, España. 2. Departamento de Cirugía General, Hospital Universitario Arnau de Vilanova, Institut de Recerca Biomèdica (IRB) de Lleida, Universitat de Lleida, Lleida, España. 3. Servicio de Endocrinología y Nutrición, Hospital Universitario Arnau de Vilanova, Institut de Recerca Biomèdica (IRB) de Lleida, Universitat de Lleida, Lleida, España; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, España. Electronic address: alecube@gmail.com.
Abstract
BACKGROUND AND OBJECTIVE: Advanced glycation end-products (AGEs) are a marker of metabolic memory. Their levels increases when oxidative stress, inflammation, or chronic hyperglycemia exists. The role of morbid obesity in AGE levels, and the impact of bariatric surgery on them are unknown. PATIENTS AND METHOD: An observational study with three sex- and age-matched cohorts: 52 patients with obesity, 46 patients undergoing bariatric surgery in the last 5 years, and 46 control subjects. AGE were measured using skin autofluorescence (SAF) in the forearm with an AGE Reader™ (DiagnOptics Technologies, Groningen, The Netherlands). Presence of metabolic syndrome was assessed. RESULTS: Patients with morbid obesity had higher SAF levels (2.14±0.65AU) than non-obese subjects (1.81±0.22AU; P<.001), which was mainly attributed to obese subjects with metabolic syndrome (2.44±0.67 vs. 1.86±0.51AU; P<.001). After bariatric surgery, SAF continued to be high (2.18±0.40AU), and greater as compared to the non-obese population (P<.001). A multivariate analysis showed that age and presence of metabolic syndrome (but not sex or body mass index) were independently associated to SAF (R2=0.320). CONCLUSION: SAF is increased in patients with morbid obesity and metabolic syndrome, mainly because of the existence of type 2 diabetes mellitus. In the first 5 years following bariatric surgery, weight loss and metabolic improvement are not associated with a parallel decrease in subcutaneous AGE levels.
BACKGROUND AND OBJECTIVE: Advanced glycation end-products (AGEs) are a marker of metabolic memory. Their levels increases when oxidative stress, inflammation, or chronic hyperglycemia exists. The role of morbid obesity in AGE levels, and the impact of bariatric surgery on them are unknown. PATIENTS AND METHOD: An observational study with three sex- and age-matched cohorts: 52 patients with obesity, 46 patients undergoing bariatric surgery in the last 5 years, and 46 control subjects. AGE were measured using skin autofluorescence (SAF) in the forearm with an AGE Reader™ (DiagnOptics Technologies, Groningen, The Netherlands). Presence of metabolic syndrome was assessed. RESULTS:Patients with morbid obesity had higher SAF levels (2.14±0.65AU) than non-obese subjects (1.81±0.22AU; P<.001), which was mainly attributed to obese subjects with metabolic syndrome (2.44±0.67 vs. 1.86±0.51AU; P<.001). After bariatric surgery, SAF continued to be high (2.18±0.40AU), and greater as compared to the non-obese population (P<.001). A multivariate analysis showed that age and presence of metabolic syndrome (but not sex or body mass index) were independently associated to SAF (R2=0.320). CONCLUSION:SAF is increased in patients with morbid obesity and metabolic syndrome, mainly because of the existence of type 2 diabetes mellitus. In the first 5 years following bariatric surgery, weight loss and metabolic improvement are not associated with a parallel decrease in subcutaneous AGE levels.
Authors: Jonas Wizenty; Teresa Schumann; Donna Theil; Martin Stockmann; Johann Pratschke; Frank Tacke; Felix Aigner; Tilo Wuensch Journal: Molecules Date: 2020-04-30 Impact factor: 4.411
Authors: Ninon Foussard; Alice Larroumet; Marine Rigo; Kamel Mohammedi; Laurence Baillet-Blanco; Pauline Poupon; Marie Monlun; Maxime Lecocq; Anne-Claire Devouge; Claire Ducos; Marion Liebart; Quentin Battaglini; Vincent Rigalleau Journal: BMJ Open Diabetes Res Care Date: 2021-03
Authors: Nataly Echevarria-Castro; Kevin Silva-Parra; Marcos Polar-Trinidad; Juan C Sánchez-Vicente; Gustavo Salinas-Sedo; Carlos J Toro-Huamanchumo Journal: J Clin Med Date: 2022-08-11 Impact factor: 4.964
Authors: Komal Waqas; Jinluan Chen; Fernando Rivadeneira; André G Uitterlinden; Trudy Voortman; M Carola Zillikens Journal: J Gerontol A Biol Sci Med Sci Date: 2022-10-06 Impact factor: 6.591