Literature DB >> 28439887

Clinical significance of recurrent copy number aberrations in B-lineage acute lymphoblastic leukaemia without recurrent fusion genes across age cohorts.

Monica Messina1, Sabina Chiaretti1, Anna Lucia Fedullo1, Alfonso Piciocchi2, Maria Cristina Puzzolo1, Alessia Lauretti1, Valentina Gianfelici1, Valerio Apicella1, Paola Fazi2, Geertruy Te Kronnie3, Anna Maria Testi1, Antonella Vitale1, Anna Guarini1,4, Robin Foà1.   

Abstract

Copy number aberrations (CNAs) represent cooperating events in B-lineage acute lymphoblastic leukaemia (B-ALL); however, their clinical relevance across different age cohorts is unclear. We analysed the recurrent CNAs in 157 age-stratified B-ALL negative cases for recurrent rearrangements (B-NEG ALL), and their association with patients' clinico-biological features. We found that: (i) CDKN2A/RB1-deleted and EBF1-deleted adults had a shorter disease-free survival than those with wild-type, (ii) among the unfavourable markers, CDKN2A/RB1 deletions and K/NRAS mutations retained their impact in multivariate analysis, encouraging the evaluation of CDKN2A/RB1 deletions and RAS mutations in the diagnostic/prognostic workflow to refine ALL risk assessment.
© 2017 John Wiley & Sons Ltd.

Entities:  

Keywords:  zzm321990CDKN2Azzm321990; zzm321990K/NRASzzm321990; acute lymphoblastic leukaemia; copy number aberrations (CNAs); prognostic markers

Mesh：

Substances：

Year:  2017        PMID： 28439887     DOI： 10.1111/bjh.14721

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  9 in total

Review 1.  Prognostic Impact of Somatic Copy Number Alterations in Childhood B-Lineage Acute Lymphoblastic Leukemia.

Authors:  Beatriz Rosales-Rodríguez; Juan Carlos Núñez-Enríquez; Juan Manuel Mejía-Aranguré; Haydeé Rosas-Vargas
Journal:  Curr Oncol Rep       Date:  2020-11-14       Impact factor: 5.075

2.  Rapid identification of BCR/ABL1-like acute lymphoblastic leukaemia patients using a predictive statistical model based on quantitative real time-polymerase chain reaction: clinical, prognostic and therapeutic implications.

Authors:  Sabina Chiaretti; Monica Messina; Sara Grammatico; Alfonso Piciocchi; Anna L Fedullo; Filomena Di Giacomo; Nadia Peragine; Valentina Gianfelici; Alessia Lauretti; Rohan Bareja; Maria P Martelli; Marco Vignetti; Valerio Apicella; Antonella Vitale; Loretta S Li; Cyril Salek; Olivier Elemento; Giorgio Inghirami; David M Weinstock; Anna Guarini; Robin Foà
Journal:  Br J Haematol       Date:  2018-04-19       Impact factor: 6.998

3.  Prognostic implications of additional genomic lesions in adult Philadelphia chromosome-positive acute lymphoblastic leukemia.

Authors:  Anna Lucia Fedullo; Monica Messina; Loredana Elia; Alfonso Piciocchi; Valentina Gianfelici; Alessia Lauretti; Stefano Soddu; Maria Cristina Puzzolo; Clara Minotti; Felicetto Ferrara; Bruno Martino; Patrizia Chiusolo; Valeria Calafiore; Stefania Paolini; Marco Vignetti; Antonella Vitale; Anna Guarini; Robin Foà; Sabina Chiaretti
Journal:  Haematologica       Date:  2018-09-06       Impact factor: 9.941

Review 4.  The Yin and Yang-Like Clinical Implications of the CDKN2A/ARF/CDKN2B Gene Cluster in Acute Lymphoblastic Leukemia.

Authors:  Celia González-Gil; Jordi Ribera; Josep Maria Ribera; Eulàlia Genescà
Journal:  Genes (Basel)       Date:  2021-01-09       Impact factor: 4.096

5.  Recurrent somatic mutations and low germline predisposition mutations in Korean ALL patients.

Authors:  Sang-Yong Shin; Hyeonah Lee; Seung-Tae Lee; Jong Rak Choi; Chul Won Jung; Hong Hoe Koo; Sun-Hee Kim
Journal:  Sci Rep       Date:  2021-04-26       Impact factor: 4.379

Review 6.  Prognostic significance of copy number variation in B-cell acute lymphoblastic leukemia.

Authors:  Yang Song; Qiuyun Fang; Yingchang Mi
Journal:  Front Oncol       Date:  2022-08-04       Impact factor: 5.738

7.  Philadelphia-like acute lymphoblastic leukemia is associated with minimal residual disease persistence and poor outcome. First report of the minimal residual disease-oriented GIMEMA LAL1913.

Authors:  Sabina Chiaretti; Monica Messina; Irene Della Starza; Alfonso Piciocchi; Luciana Cafforio; Marzia Cavalli; Akram Taherinasab; Michela Ansuinelli; Loredana Elia; Guglielmo Albertini Petroni; Roberta La Starza; Martina Canichella; Alessia Lauretti; Maria Cristina Puzzolo; Valentina Pierini; Alessandra Santoro; Orietta Spinelli; Valerio Apicella; Saveria Capria; Francesco Di Raimondo; Paolo De Fabritiis; Cristina Papayannidis; Anna Candoni; Roberto Cairoli; Marco Cerrano; Nicola Fracchiolla; Daniele Mattei; Chiara Cattaneo; Antonella Vitale; Enrico Crea; Paola Fazi; Cristina Mecucci; Alessandro Rambaldi; Anna Guarini; Renato Bassan; Robin Foà
Journal:  Haematologica       Date:  2021-06-01       Impact factor: 9.941

8.  Gene Deletions and Prognostic Values in B-Linage Acute Lymphoblastic Leukemia.

Authors:  Qiuyun Fang; Yang Song; Xiaoyuan Gong; Jun Wang; Qinghua Li; Kaiqi Liu; Yahui Feng; Qishan Hao; Yan Li; Hui Wei; Guangji Zhang; Yuntao Liu; Benfa Gong; Ying Wang; Chunlin Zhou; Dong Lin; Bingcheng Liu; Shuning Wei; Runxia Gu; Yingchang Mi; Jianxiang Wang
Journal:  Front Oncol       Date:  2021-06-02       Impact factor: 6.244

9.  Copy Number Alteration Profile Provides Additional Prognostic Value for Acute Lymphoblastic Leukemia Patients Treated on BFM Protocols.

Authors:  Mirella Ampatzidou; Lina Florentin; Vassilios Papadakis; Georgios Paterakis; Marianna Tzanoudaki; Dimitra Bouzarelou; Stefanos I Papadhimitriou; Sophia Polychronopoulou
Journal:  Cancers (Basel)       Date:  2021-06-30       Impact factor: 6.639
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.