Georgi Tchernev1,2, Ilia Lozev3, Ivan Pidakev3, Hristo Mangarov4, Yavor Grigorov5, José Carlos Cardoso6, Elisaveta Popchristova3, James W Patterson7, Torello Lotti8,9, Georgi Pehlivanov10, Cristiana Voicu11, Victor Gabriel Clatici12, Uwe Wollina13. 1. Department of Dermatology and Dermatologic Surgery, Medical Institute of Ministry of Interior (MVR), General Skobelev 79, 1606, Sofia, Bulgaria. georgi_tchernev@yahoo.de. 2. Venereology and Dermatologic Surgery, Onkoderma - Policlinic for Dermatology, 26 General Skobelev blvd, Sofia, Bulgaria. georgi_tchernev@yahoo.de. 3. Department of General, Vascular and Abdominal Surgery, Medical Institute of Ministry of Interior, General Skobelev 79, 1606, Sofia, Bulgaria. 4. Department of Dermatology and Dermatologic surgery, Medical Institute of Ministry of Interior (MVR), General Skobelev 79, 1606, Sofia, Bulgaria. 5. Department of Orthopedics and Traumatology, University Hospital Lozenetz, 1 Koziak Street, Sofia, Bulgaria. 6. St John's Institute of Dermatology, Department of Dermatopathology, London, UK. 7. Department of Pathology, University of Virginia Health System, 1215 Lee Street, 800214, 22908, Charlottesville, VA, USA. 8. Department of Dermatology, University of Rome "G. Marconi", Rome, Italy. 9. Department of Biotechnology, Delft University of Technology, 2628 BC, Delft, The Netherlands. 10. Department of Dermatology and Venereology, Alexanders Hospital, Sofia, Bulgaria. 11. Dermatology Department, Polisano Clinic, 26Z Timisoara Blvd, Bucharest, Romania. 12. Oncologic Dermatology and Allergology Department, Elias Emergency Hospital, 17 Marasti Blvd, Bucharest, Romania. 13. Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Friedrichstrasse 41, 01067, Dresden, Germany.
Abstract
BACKGROUND: Interdigital melanoma, as a subtype of acral lentiginous melanoma, is relatively uncommon in the Caucasian population. It frequently goes unrecognized for a prolonged period of time prior to diagnosis, due to its asymptomatic nature and variable clinical appearance. METHODS: We report the case of a 67-year-old Caucasian woman who presented with interdigital malignant melanoma affecting two neighboring interdigital spaces. It had evolved over a period of more than 15 years and had been initially misdiagnosed as tinea pedis due to the macerated appearance of the lesion and a positive mycologic examination. RESULTS: We highlight the striking involvement of two adjacent interdigital spaces and the neighboring area of the sole of the foot by the tumor. The melanoma was staged as IIIC, with pathologic grading T4bN2bM CONCLUSIONS: The involvement of two adjacent interdigital spaces is unusual and, to our knowledge, has not been previously highlighted in the medical literature. It may be explained, in part, by the longstanding nature of the lesion in our patient.
BACKGROUND:Interdigital melanoma, as a subtype of acral lentiginous melanoma, is relatively uncommon in the Caucasian population. It frequently goes unrecognized for a prolonged period of time prior to diagnosis, due to its asymptomatic nature and variable clinical appearance. METHODS: We report the case of a 67-year-old Caucasian woman who presented with interdigital malignant melanoma affecting two neighboring interdigital spaces. It had evolved over a period of more than 15 years and had been initially misdiagnosed as tinea pedis due to the macerated appearance of the lesion and a positive mycologic examination. RESULTS: We highlight the striking involvement of two adjacent interdigital spaces and the neighboring area of the sole of the foot by the tumor. The melanoma was staged as IIIC, with pathologic grading T4bN2bM CONCLUSIONS: The involvement of two adjacent interdigital spaces is unusual and, to our knowledge, has not been previously highlighted in the medical literature. It may be explained, in part, by the longstanding nature of the lesion in our patient.
Authors: Seaver L Soon; Alvin R Solomon; Diamondis Papadopoulos; Douglas R Murray; Barbara McAlpine; Carl V Washington Journal: J Am Acad Dermatol Date: 2003-02 Impact factor: 11.527
Authors: Georgi Tchernev; Ivan Pidakev; Anastasiya Atanasova Chokoeva; Uwe Wollina; Torello Lotti; Irina Yungareva; Ilia Lozev; Georgi Konstantinov Maximov Journal: Open Access Maced J Med Sci Date: 2018-01-13